Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y4C1 | hypoxia can stimulate enzyme mRNA and protein expression, involving binding of hypoxia-induced factor 1 to a specific hypoxia responsive element in the enzyme's promoter | - |
Rattus norvegicus | Q63679 | hypoxia can stimulate enzyme mRNA and protein expression involving binding of hypoxia-induced factor 1 to a specific hypoxia responsive element in the enzyme's promoter | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | high basal expression with 2.3-fold increase in mRNA after 6 h of hypoxia | Rattus norvegicus | - |
heart | 3.3fold increase in mRNA after 6 h of hypoxia | Rattus norvegicus | - |
HEK-293 cell | up-regulation of mRNA and protein after exposure to hypoxia or iron scavengers in vitro. Blocking of hypoxia-inducible factor 1 signaling abrogates the up-regulation | Homo sapiens | - |
kidney | 1.8fold increase in mRNA after 6 h of hypoxia | Rattus norvegicus | - |
liver | 7.7fold increase in mRNA after 6 h of hypoxia | Rattus norvegicus | - |
additional information | mRNA expression is increased in most tissues of human fetuses in whom oxygen supply is low compared to postnatal levels | Homo sapiens | - |