Cloned (Comment) | Organism |
---|---|
heterologous-pathway reconstitution in Nicotiana benthamiana | Arabidopsis thaliana |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
scopoletin + 2-oxoglutarate + O2 | Arabidopsis thaliana | the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants | fraxetin + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q9LE86 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
root | expressed most strongly in the root epidermal layer under iron-deficient conditions | Arabidopsis thaliana | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
scopoletin + 2-oxoglutarate + O2 | - |
Arabidopsis thaliana | fraxetin + succinate + CO2 | - |
? | |
scopoletin + 2-oxoglutarate + O2 | the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants | Arabidopsis thaliana | fraxetin + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
At3g12900 | - |
Arabidopsis thaliana |
S8H | - |
Arabidopsis thaliana |
Organism | Comment | Expression |
---|---|---|
Arabidopsis thaliana | iron-deficiency-dependent upregulation. The iron-deficiency-dependent upregulation is mainly confined to roots | up |
General Information | Comment | Organism |
---|---|---|
metabolism | the enzyme is involved in biosynthesis of iron(III)-chelating coumarins in higher plants. Under iron-deficiency conditions, a branch of the phenylpropanoid pathway consisting of feruloyl-CoA 6'-hydroxylase 1, scopoletin 8-hydroxylase, and CYP82C4 is strongly induced, thus leading to the synthesis of scopoletin and its conversion into redox-active fraxetin and sideretin. In the rhizosphere, the redox-active coumarins act in concert with other components of the strategy I iron acquisition machinery by solubilizing and reducing iron from sparingly available sources | Arabidopsis thaliana |