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Literature summary for 1.14.11.4 extracted from

  • Stein, H.; Wilensky, M.; Tsafrir, Y.; Rosenthal, M.; Amir, R.; Avraham, T.; Ofir, K.; Dgany, O.; Yayon, A.; Shoseyov, O.
    Production of bioactive, post-translationally modified, heterotrimeric, human recombinant type-I collagen in transgenic tobacco (2009), Biomacromolecules, 10, 2640-2645.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
expression of a synthetic gene encoding LH3, SEQ ID, in Nicotiana tabacum leaves. Co-expression of the human genes encoding recombinant heterotrimeric collagen type I, rhCOL1, the human prolyl-4-hydroxylase, and the lysyl hydroxylase 3, all responsible for key posttranslational modifications of collagen. Plants coexpressing all five vacuole-targeted proteins generate intact procollagen yields ofabout 2% of the extracted total soluble protein, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-lysine-[collagen] + 2-oxoglutarate + O2 Homo sapiens
-
 5-hydroxy-L-lysine-[collagen] + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme LH3
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-lysine-[collagen] + 2-oxoglutarate + O2
-
 Homo sapiens 5-hydroxy-L-lysine-[collagen] + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
LH3
-
 Homo sapiens
lysyl hydroxylase 3
-
 Homo sapiens