Cloned (Comment) | Organism |
---|---|
expression of active LH2b and of antisense construct in MC3T3-E1 cells, the latter suppresses the endogenous enzyme | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-lysine + 2-oxoglutarate + O2 | Mus musculus | isozyme LH2b directs the collagen cross-linking pathways, lysine hydroxylation as post-translational modification critical for collagen cross-linking and glycosylation, isozyme LH2 modulates the cross-linking pattern | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
3 isozymes LH1-3, isozyme LH2 occurs in 2 splicing variant, 2a and 2b, the first without insert | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
kidney | - |
Mus musculus | - |
MC3T3-E1 cell | different clones, osteoblastic cell line, expression of splicing vaiant 2b of isozyme LH2, but not of splicing variant 2a, expression analysis of the 3 isozymes in MC3T3-E1 cells and comparison of collagen cross-linking activities, overview | Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procollagen L-lysine + 2-oxoglutarate + O2 | - |
Mus musculus | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
procollagen L-lysine + 2-oxoglutarate + O2 | isozyme LH2b directs the collagen cross-linking pathways, lysine hydroxylation as post-translational modification critical for collagen cross-linking and glycosylation, isozyme LH2 modulates the cross-linking pattern | Mus musculus | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LH2b | - |
Mus musculus |
Lysyl hydroxylase-2b | - |
Mus musculus |