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Literature summary for 1.14.11.4 extracted from
- Identification, expression, and tissue distribution of the three rat lysyl hydroxylase isoforms (2003), Biochem. Biophys. Res. Commun., 307, 803-809.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of 3 isozymes LH1-3, with 2 splicing variants of isozyme LH2, LH2a and LH2b, stable and functional expression in CHO-K1 cells | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| procollagen L-lysine + 2-oxoglutarate + O2 | Rattus norvegicus | hydroxylation of lysine residues collagen causes cross-linking with pyrolidine | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
3 isozymes LH1-3 | - |
| Rattus norvegicus | Q811A3 | isozyme LH2b; 3 isozymes LH1-3 | - |
| Rattus norvegicus | Q811A3 | ospzyme LH2a; 3 isozymes LH1-3 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | stem marrow cell, no expression of isozymes LH3 and LH2b | Rattus norvegicus | - |
| brain | - |
Rattus norvegicus | - |
| cartilage | zyphoid | Rattus norvegicus | - |
| colon | distal | Rattus norvegicus | - |
| heart | - |
Rattus norvegicus | - |
| hepatocyte | - |
Rattus norvegicus | - |
| hindlimb | - |
Rattus norvegicus | - |
| INS-1 cell | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| lung | - |
Rattus norvegicus | - |
| additional information | isozymes LH1 and LH2a are expressed in all tissues, isozymes LH2b and LH3 are expressed in almost all tissues, no tissue specificity | Rattus norvegicus | - |
| additional information | the 3 isozymes are expressed in almost all tissues, no tissue specificity | Rattus norvegicus | - |
| pancreatic duct | - |
Rattus norvegicus | - |
| skeletal muscle | from leg | Rattus norvegicus | - |
| skin | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isozyme LH2a possesses telopeptide lysyl hydroxylase activity | Rattus norvegicus | ? | - |
? | |
| procollagen L-lysine + 2-oxoglutarate + O2 | - |
Rattus norvegicus | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
| procollagen L-lysine + 2-oxoglutarate + O2 | hydroxylation of lysine residues collagen causes cross-linking with pyrolidine | Rattus norvegicus | procollagen 5-hydroxy-L-lysine + succinate + CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LH | - |
Rattus norvegicus |
| lysyl hydroxylase | - |
Rattus norvegicus |
| PLOD | - |
Rattus norvegicus |
| procollagen-lysine 2-oxoglutarate 5-dioxygenase | - |
Rattus norvegicus |
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