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Literature summary for 1.14.11.33 extracted from

  • Wang, P.; Wu, J.; Ma, S.; Zhang, L.; Yao, J.; Hoadley, K.A.; Wilkerson, M.D.; Perou, C.M.; Guan, K.L.; Ye, D.; Xiong, Y.
    Oncometabolite D-2-hydroxyglutarate inhibits ALKBH DNA repair enzymes and sensitizes IDH mutant cells to alkylating agents (2015), Cell Rep., 13, 2353-2361 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
D-2-hydroxyglutarate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA-1-methyladenine + 2-oxoglutarate + O2 Homo sapiens
-
DNA-adenine + formaldehyde + succinate + CO2
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2 Homo sapiens
-
DNA-cytosine + formaldehyde + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1080 cell
-
Homo sapiens
-
U87-MG cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA-1-methyladenine + 2-oxoglutarate + O2
-
Homo sapiens DNA-adenine + formaldehyde + succinate + CO2
-
?
DNA-1-methyldeoxyadenine + 2-oxoglutarate + O2
-
Homo sapiens DNA-deoxyadenine + formaldehyde + succinate + CO2
-
?
DNA-3-methylcytosine + 2-oxoglutarate + O2
-
Homo sapiens DNA-cytosine + formaldehyde + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
ALKBH2 isoform Homo sapiens
ALKBH3 isoform Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.5
-
isoform ALKBH2, pH and temperature not specified in the publication Homo sapiens D-2-hydroxyglutarate