Crystallization (Comment) | Organism |
---|---|
isoform PHD2 in complex with Mn2+, sitting drop vapor diffusion method, using 1.6 M sodium citrate/citric acid pH 6.5 | Homo sapiens |
isoform PHD2 in complex with Mn2+, sitting drop vapor diffusion method, using 1.6 M sodium citrate/citric acid pH 6.5 | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-carboxylic acid | - |
Homo sapiens | |
6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-carboxylic acid | - |
Mus musculus | |
dimethyloxalylglycine | - |
Homo sapiens | |
dimethyloxalylglycine | - |
Mus musculus | |
N-oxalylglycine | - |
Homo sapiens | |
N-oxalylglycine | - |
Mus musculus | |
tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate | potent and selective inhibitor of isoform PHD2 | Homo sapiens | |
tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate | potent and selective inhibitor of isoform PHD2 | Mus musculus | |
[(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid | - |
Homo sapiens | |
[(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid | - |
Mus musculus | |
[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid | - |
Homo sapiens | |
[(1-chloro-4-hydroxyisoquinoline-3-carbonyl)amino]acetic acid | - |
Mus musculus | |
[(2E)-3-hydroxy-2-({[(naphthalen-2-yl)methanesulfonyl]acetyl}imino)-2,3-dihydro-1,3-thiazol-4-yl]acetic acid | - |
Homo sapiens | |
[(2E)-3-hydroxy-2-({[(naphthalen-2-yl)methanesulfonyl]acetyl}imino)-2,3-dihydro-1,3-thiazol-4-yl]acetic acid | - |
Mus musculus | |
[(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid | - |
Homo sapiens | |
[(4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96KS0 | - |
- |
Homo sapiens | Q9GZT9 | - |
- |
Homo sapiens | Q9H6Z9 | - |
- |
Mus musculus | Q91UZ4 | - |
- |
Mus musculus | Q91YE2 | - |
- |
Mus musculus | Q91YE3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
HeLa cell | - |
Homo sapiens | - |
HEP-3B cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
MCF-7 cell | - |
Homo sapiens | - |
RCC-4 cell | - |
Homo sapiens | - |
U2OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DLDLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Homo sapiens | ? | - |
? | |
DLDLEMLAPYIPMDDDFQL + 2-oxoglutarate + O2 | - |
Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Hif-prolyl hydroxylase | - |
Homo sapiens |
Hif-prolyl hydroxylase | - |
Mus musculus |
PHD1 | isoform | Homo sapiens |
PHD1 | isoform | Mus musculus |
PHD2 | isoform | Homo sapiens |
PHD2 | isoform | Mus musculus |
PHD3 | isoform | Homo sapiens |
PHD3 | isoform | Mus musculus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000016 | - |
isoform PHD2, pH and temperature not specified in the publication | Homo sapiens | tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate | |
0.0000016 | - |
isoform PHD2, pH and temperature not specified in the publication | Mus musculus | tert-butyl 6-(5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl)nicotinate | |
0.0000022 | - |
isoform PHD2, pH and temperature not specified in the publication | Homo sapiens | N-oxalylglycine | |
0.0000022 | - |
isoform PHD2, pH and temperature not specified in the publication | Mus musculus | N-oxalylglycine | |
0.0000048 | - |
isoform PHD2, pH and temperature not specified in the publication | Homo sapiens | 6-[5-oxo-4-(1H-1,2,3-triazol-1-yl)-2,5-dihydro-1H-pyrazol-1-yl]pyridine-3-carboxylic acid | |
0.000022 | - |
isoform PHD2, pH and temperature not specified in the publication | Homo sapiens | [(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)amino]acetic acid |