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Literature summary for 1.14.11.29 extracted from

  • Bishop, T.; Ratcliffe, P.J.
    HIF hydroxylase pathways in cardiovascular physiology and medicine (2015), Circ. Res., 117, 65-79 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
FG-2216
-
Homo sapiens
GSK360A
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 Homo sapiens
-
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
Homo sapiens hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
?

Synonyms

Synonyms Comment Organism
EGLN1 isoform Homo sapiens
Egln2 isoform Homo sapiens
EGLN3 isoform Homo sapiens
HIF prolyl hydroxylase
-
Homo sapiens
PHD1 isoform Homo sapiens
PHD2 isoform Homo sapiens
PHD3 isoform Homo sapiens