Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid | - |
Homo sapiens | |
(2S)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid | - |
Homo sapiens | |
2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methylthiazol-4-yl)-N-(2-(diethylamino)ethyl)acetamide | - |
Homo sapiens | |
2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide | - |
Homo sapiens | |
2-(2-(5-cyano-3-hydroxypyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(diethylamino)ethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-propylacetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-(2-phenylethyl)acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | - |
Homo sapiens | |
2-[2-(5-cyano-3-hydroxypyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | - |
Homo sapiens | |
2-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]-2-methylpropanoic acid | - |
Homo sapiens | |
5-hydroxy-6-[4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3-thiazol-2-yl]pyridine-3-carbonitrile | - |
Homo sapiens | |
AKB-6548 | - |
Homo sapiens | |
BAY85-3934 | - |
Homo sapiens | |
deferoxamine | - |
Homo sapiens | |
FG-0041 | - |
Homo sapiens | |
FG-2216 | - |
Homo sapiens | |
FG-4592 | - |
Homo sapiens | |
GSK1278863 | - |
Homo sapiens | |
GSK360A | - |
Homo sapiens | |
N-benzyl-2-[2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide | - |
Homo sapiens | |
N-benzyl-2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide | - |
Homo sapiens | |
N-oxalylglycine | - |
Homo sapiens | |
PN-3602 | - |
Homo sapiens | |
[2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid | - |
Homo sapiens | |
[2-(3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid | - |
Homo sapiens | |
[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid | - |
Homo sapiens | |
[2-(5-cyano-3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid | - |
Homo sapiens | |
[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]acetic acid | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | Homo sapiens | - |
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 | - |
Homo sapiens | hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HIF prolyl 4-hydroxylase | - |
Homo sapiens |
PHD | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0004 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methylthiazol-4-yl)-N-(2-(diethylamino)ethyl)acetamide | |
0.0007 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | |
0.0008 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | |
0.0012 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxypyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | |
0.0014 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-methyl-1,3-thiazol-4-yl]-N-propylacetamide | |
0.002 | - |
pH and temperature not specified in the publication | Homo sapiens | 5-hydroxy-6-[4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]-1,3-thiazol-2-yl]pyridine-3-carbonitrile | |
0.0021 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1R)-2-hydroxy-1-phenylethyl]acetamide | |
0.0022 | - |
pH and temperature not specified in the publication | Homo sapiens | [2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]acetic acid | |
0.0024 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[(1S)-2-hydroxy-1-phenylethyl]acetamide | |
0.0026 | - |
pH and temperature not specified in the publication | Homo sapiens | (2R)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid | |
0.0028 | - |
pH and temperature not specified in the publication | Homo sapiens | (2S)-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido](phenyl)acetic acid | |
0.003 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(pyridin-2-yl)ethyl]acetamide | |
0.0034 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]-N-(2-phenylethyl)acetamide | |
0.0038 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-1,3-thiazol-4-yl]-N-[2-(diethylamino)ethyl]acetamide | |
0.0039 | - |
pH and temperature not specified in the publication | Homo sapiens | FG-2216 | |
0.0054 | - |
pH and temperature not specified in the publication | Homo sapiens | N-benzyl-2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide | |
0.0057 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(2-(5-cyano-3-hydroxy-4-methylpyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide | |
0.006 | - |
pH and temperature not specified in the publication | Homo sapiens | [2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid | |
0.0073 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-[2-[2-(5-cyano-3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamido]-2-methylpropanoic acid | |
0.0135 | - |
pH and temperature not specified in the publication | Homo sapiens | [2-(5-cyano-3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid | |
0.024 | - |
pH and temperature not specified in the publication | Homo sapiens | 2-(2-(5-cyano-3-hydroxypyridin-2-yl)-5-phenylthiazol-4-yl)-N-(2-(pyridin-2-yl)ethyl)acetamide | |
0.0275 | - |
pH and temperature not specified in the publication | Homo sapiens | [2-(3-hydroxypyridin-2-yl)-6-oxo-1,6-dihydropyrimidin-5-yl]acetic acid | |
0.081 | - |
pH and temperature not specified in the publication | Homo sapiens | N-benzyl-2-[2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetamide | |
0.195 | - |
pH and temperature not specified in the publication | Homo sapiens | [2-(3-hydroxypyridin-2-yl)-1,3-thiazol-4-yl]acetic acid |