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Literature summary for 1.14.11.29 extracted from

  • Chen, N.; Huang, C.H.; Chen, B.X.; Liu, H.; Wang, W.M.; Gul, Y.; Wang, H.L.
    Alternative splicing transcription of Megalobrama amblycephala HIF prolyl hydroxylase PHD3 and up-regulation of PHD3 by HIF-1alpha (2016), Biochem. Biophys. Res. Commun., 469, 737-742 .
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2 Megalobrama amblycephala
-
hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Megalobrama amblycephala A0A140EDB6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Megalobrama amblycephala
-
brain
-
Megalobrama amblycephala
-
embryo detected only in the initial stages of embryo development Megalobrama amblycephala
-
gill
-
Megalobrama amblycephala
-
heart
-
Megalobrama amblycephala
-
intestine
-
Megalobrama amblycephala
-
kidney
-
Megalobrama amblycephala
-
liver high expression Megalobrama amblycephala
-
muscle
-
Megalobrama amblycephala
-
spleen
-
Megalobrama amblycephala
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
hypoxia-inducible factor-L-proline + 2-oxoglutarate + O2
-
Megalobrama amblycephala hypoxia-inducible factor-trans-4-hydroxy-L-proline + succinate + CO2
-
?

Subunits

Subunits Comment Organism
? x * 26845, calculated from amino acid sequence Megalobrama amblycephala

Synonyms

Synonyms Comment Organism
HIF prolyl hydroxylase
-
Megalobrama amblycephala
PHD3
-
Megalobrama amblycephala

Expression

Organism Comment Expression
Megalobrama amblycephala after hypoxia treatment the enzyme expression is significantly increased in all analyzed tissues up

General Information

General Information Comment Organism
physiological function isoform PHD3 plays important roles in hypoxia response and early embryo development of Megalobrama amblycephala Megalobrama amblycephala