Literature summary for 1.14.11.29 extracted from

Kwon, H.S.; Choi, Y.K.; Kim, J.W.; Park, Y.K.; Yang, E.G.; Ahn, D.R.
Inhibition of a prolyl hydroxylase domain (PHD) by substrate analog peptides (2011), Bioorg. Med. Chem. Lett., 21, 4325-4328.

Search for more literature for 1.14.11.29

Cloned(Commentary)

Cloned (Comment)	Organism
recombinant expression of GST-tagged PHD2	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
DLDLEALA-L-3,4-dehydroproline-YIPADDDFQLR	-	Homo sapiens
DLDLEALA-L-4-thioproline-YIPADDDFQLR	-	Homo sapiens
DLDLEALA-L-piperidine-2-carboxylic acid-YIPADDDFQLR	-	Homo sapiens
DLDLEALA-L-trans-4-fluoroproline-YIPADDDFQLR	-	Homo sapiens
DLDLEALA-L-trans-4-hydroxyproline-YIPADDDFQLR	-	Homo sapiens
additional information	the peptide inhibitors consist of amino acids identical to those in the CODD556-575 except the 564 proline residue, and target the C-terminal oxygen-dependent degradation domain binding site in the PHD2 active pocket. Specific inhibition of PHD2, no inhibition of FIH, EC 1.14.11.30	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe2+	dependent on	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hypoxia-inducible factor-proline + 2-oxoglutarate + O2	Homo sapiens	HIF-1alpha	hypoxia-inducible factor-(3S)-3-hydroxy-proline + succinate + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme PHD2	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant GST-tagged PHD2 by glutathione affinity chromatography	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hypoxia-inducible factor-proline + 2-oxoglutarate + O2	HIF-1alpha	Homo sapiens	hypoxia-inducible factor-(3S)-3-hydroxy-proline + succinate + CO2	-	?

Synonyms

Synonyms	Comment	Organism
PHD	-	Homo sapiens
PHD2	-	Homo sapiens
proline hydroxylase domain 2	-	Homo sapiens
prolyl hydroxylase domain	-	Homo sapiens

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Release 2023.1 (January 2023)