Cloned (Comment) | Organism |
---|---|
recombinant expression of GST-tagged PHD2 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DLDLEALA-L-3,4-dehydroproline-YIPADDDFQLR | - |
Homo sapiens | |
DLDLEALA-L-4-thioproline-YIPADDDFQLR | - |
Homo sapiens | |
DLDLEALA-L-piperidine-2-carboxylic acid-YIPADDDFQLR | - |
Homo sapiens | |
DLDLEALA-L-trans-4-fluoroproline-YIPADDDFQLR | - |
Homo sapiens | |
DLDLEALA-L-trans-4-hydroxyproline-YIPADDDFQLR | - |
Homo sapiens | |
additional information | the peptide inhibitors consist of amino acids identical to those in the CODD556-575 except the 564 proline residue, and target the C-terminal oxygen-dependent degradation domain binding site in the PHD2 active pocket. Specific inhibition of PHD2, no inhibition of FIH, EC 1.14.11.30 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | dependent on | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-proline + 2-oxoglutarate + O2 | Homo sapiens | HIF-1alpha | hypoxia-inducible factor-(3S)-3-hydroxy-proline + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
isozyme PHD2 | - |
Purification (Comment) | Organism |
---|---|
recombinant GST-tagged PHD2 by glutathione affinity chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypoxia-inducible factor-proline + 2-oxoglutarate + O2 | HIF-1alpha | Homo sapiens | hypoxia-inducible factor-(3S)-3-hydroxy-proline + succinate + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PHD | - |
Homo sapiens |
PHD2 | - |
Homo sapiens |
proline hydroxylase domain 2 | - |
Homo sapiens |
prolyl hydroxylase domain | - |
Homo sapiens |