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Literature summary for 1.14.11.27 extracted from
- Epigenetic regulation: methylation of histone and non-histone proteins (2009), Sci. China C Life Sci., 52, 311-322.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| HP1a | H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association | Drosophila melanogaster |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Drosophila melanogaster | dynamic nature of histone methylation regulation on four of the main lysine sites of methylation on histone H3 and H4 tails, i.e. H3K4, H3K9, H3K27 and H3K36, overview. Methylation of non-histone proteins may be a general means to regulate epigenetic information | ? | - |
? |  |
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | Drosophila melanogaster | H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | dynamic nature of histone methylation regulation on four of the main lysine sites of methylation on histone H3 and H4 tails, i.e. H3K4, H3K9, H3K27 and H3K36, overview. Methylation of non-histone proteins may be a general means to regulate epigenetic information | Drosophila melanogaster | ? | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | - |
Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
| [histone H3]-N6,N6-dimethyl-L-lysine36 + 2 2-oxoglutarate + 2 O2 | H3K36 demethylation activity of the fly dKDM4A is dramatically stimulated upon HP1a association | Drosophila melanogaster | [histone H3]-L-lysine36 + 2 succinate + 2 formaldehyde + 2 CO2 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dKDM4A | - |
Drosophila melanogaster |
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