Cloned (Comment) | Organism |
---|---|
expression in mouse embryo fibroblast | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of histone demthylase Ndy1 in mouse embryo fibroblast results in immortalization in absence of replicative senescence via a JmjC domain-dependent process that targets the Rb and p53 pathways. Knockdown of endogenous Ndy1 or expression of JmjC domain mutants of Ndy1 promote senescence, suggesting that Ndy1 is a physiological inhibitor of senescence in dividing cells and that inhibition of senescence depends on histone H3 demethylation | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
histone demethylases Ndy1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lymphoma cell | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation | Rattus norvegicus | ? | - |
? |