Cloned (Comment) | Organism |
---|---|
gene P4halpha1, quantitative real-time PCR enzyme expression analysis | Rattus norvegicus |
gene P4halpha1, quantitative real-time PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | P4halpha1 gene silencing by specific siRNA expression in human aortic smooth muscle cells | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Rattus norvegicus | |
Fe2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P13674 | - |
- |
Rattus norvegicus | P54001 | - |
- |
Rattus norvegicus Wistar | P54001 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Homo sapiens | - |
aorta | rat abdominal aortas | Rattus norvegicus | - |
blood vessel | - |
Rattus norvegicus | - |
blood vessel | - |
Homo sapiens | - |
smooth muscle cell | aortic | Rattus norvegicus | - |
smooth muscle cell | aortic | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
P4H alpha1 | - |
Rattus norvegicus |
P4H alpha1 | - |
Homo sapiens |
prolyl-4-hydroxylase alpha1 | - |
Rattus norvegicus |
prolyl-4-hydroxylase alpha1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Rattus norvegicus |
7.5 | - |
assay at | Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | mechanical stretch increases MMP-2 and P4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 significantly attenuates the stretch-induced upregulation of P4H alpha1 expression, whereas blockade of the ERK1/2 pathway has no effect on P4H alpha1 expression | up |
Rattus norvegicus | the enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling | up |
General Information | Comment | Organism |
---|---|---|
physiological function | prolyl-4-hydroxylase alpha1 and matrix metalloproteinases are essential for collagen synthesis and degradation. The enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling, mechanical stretch increases MMP-2 andP4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. .. MMP-2 and P4Halpha1 participate in collagen metabolism induced by pathologic mechanical stretch | Rattus norvegicus |
physiological function | prolyl-4-hydroxylase alpha1 and matrix metalloproteinases are essential for collagen synthesis and degradation. The enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling, mechanical stretch increases MMP-2 andP4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling.. MMP-2 and P4Halpha1 participate in collagen metabolism induced by pathologic mechanical stretch | Homo sapiens |