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Literature summary for 1.14.11.2 extracted from

  • Liu, X.; Huang, X.; Chen, L.; Zhang, Y.; Li, M.; Wang, L.; Ge, C.; Wang, H.; Zhang, M.
    Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase alpha1 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling (2015), Int. J. Biochem. Cell Biol., 62, 15-23 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene P4halpha1, quantitative real-time PCR enzyme expression analysis Rattus norvegicus
gene P4halpha1, quantitative real-time PCR enzyme expression analysis Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information P4halpha1 gene silencing by specific siRNA expression in human aortic smooth muscle cells Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Rattus norvegicus
Fe2+ required Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P13674
-
-
Rattus norvegicus P54001
-
-
Rattus norvegicus Wistar P54001
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
Homo sapiens
-
aorta rat abdominal aortas Rattus norvegicus
-
blood vessel
-
Rattus norvegicus
-
blood vessel
-
Homo sapiens
-
smooth muscle cell aortic Rattus norvegicus
-
smooth muscle cell aortic Homo sapiens
-

Synonyms

Synonyms Comment Organism
P4H alpha1
-
Rattus norvegicus
P4H alpha1
-
Homo sapiens
prolyl-4-hydroxylase alpha1
-
Rattus norvegicus
prolyl-4-hydroxylase alpha1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Rattus norvegicus
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Rattus norvegicus
7.5
-
assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens mechanical stretch increases MMP-2 and P4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. p38 MAPK inhibitor SB203580 and JNK inhibitor SP600125 significantly attenuates the stretch-induced upregulation of P4H alpha1 expression, whereas blockade of the ERK1/2 pathway has no effect on P4H alpha1 expression up
Rattus norvegicus the enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling up

General Information

General Information Comment Organism
physiological function prolyl-4-hydroxylase alpha1 and matrix metalloproteinases are essential for collagen synthesis and degradation. The enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling, mechanical stretch increases MMP-2 andP4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling. .. MMP-2 and P4Halpha1 participate in collagen metabolism induced by pathologic mechanical stretch Rattus norvegicus
physiological function prolyl-4-hydroxylase alpha1 and matrix metalloproteinases are essential for collagen synthesis and degradation. The enzyme is induced by mechanical stretch on the vessel wall, an important stimulus that also induces collagen remodeling, mechanical stretch increases MMP-2 andP4H alpha1 expression in human aortic smooth muscle cell via AKT-P38 MAPK-JNK signaling, thereby inducing vascular remodeling.. MMP-2 and P4Halpha1 participate in collagen metabolism induced by pathologic mechanical stretch Homo sapiens