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Literature summary for 1.14.11.2 extracted from

  • Cao, X.Q.; Liu, X.X.; Li, M.M.; Zhang, Y.; Chen, L.; Wang, L.; Di, M.X.; Zhang, M.
    Overexpression of prolyl-4-hydroxylase-alpha1 stabilizes but increases shear stress-induced atherosclerotic plaque in apolipoprotein E-deficient mice (2016), Dis. Markers, 2016, 1701637 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.14.11.2

Application

Application Comment Organism
medicine enzyme P4Halpha1 overexpression might be a potential therapeutic target in stabilizing vulnerable plaques to prevent rupture and erosion of atherosclerotic plaque and thus thrombosis Mus musculus

Cloned(Commentary)

Cloned (Comment) Organism
gene P4ha1, quantitative real-time PCR enzyme expression analysis Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information recombinant lentiviral-based overexpression of prolyl-4-hydroxylase-alpha1 in mice, the plaques show increased collgane accumulation but no difference of lipid accumulation. The protein expressions of TGF-beta1 are higher in lenti-P4Ha1 mice than in mock or lenti-EGFP mice. Overexpression of P4Ha1 reduced macrophage infiltration Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ required Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2 Mus musculus
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2 Mus musculus ApoE
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q60715
-
-
Mus musculus ApoE Q60715
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
procollagen L-proline + 2-oxoglutarate + O2
-
 Mus musculus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
procollagen L-proline + 2-oxoglutarate + O2
-
 Mus musculus ApoE procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
P4ha1
-
 Mus musculus
prolyl-4-hydroxylase-alpha1
-
 Mus musculus

General Information

General Information Comment Organism
malfunction overexpression of prolyl-4-hydroxylase-alpha1 stabilizes but increases shear stress-induced atherosclerotic plaque in apolipoprotein E-deficient mice. After 2 weeks of lenti-P4Halpha1 treatment both low and oscillatory shear stress-induced plaques increase collagen and the thickness of fibrous cap and decreases macrophage accumulation but show no change in lipid accumulation Mus musculus
physiological function prolyl-4-hydroxylase (P4H) plays a central role in the synthesis of all known types of collagens, which are the most abundant constituent of the extracellular matrix in atherosclerotic plaque. Isozyme P4Halpha1 is a rate-limiting enzyme and is essential for collagen maturation and secretion Mus musculus