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Literature summary for 1.14.11.17 extracted from

  • Ali, H.S.; de Visser, S.P.
    Electrostatic perturbations in the substrate-binding pocket of taurine/alpha-ketoglutarate dioxygenase determine its selectivity (2022), Chemistry, 28, e202104167.
    View publication on PubMed
Search for more literature for 1.14.11.17

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
taurine + 2-oxoglutarate + O2 Escherichia coli
-
 sulfite + aminoacetaldehyde + succinate + CO2
-
 ?
taurine + 2-oxoglutarate + O2 Escherichia coli K12
-
 sulfite + aminoacetaldehyde + succinate + CO2
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli P37610
-
-
Escherichia coli K12 P37610
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
taurine + 2-oxoglutarate + O2
-
 Escherichia coli sulfite + aminoacetaldehyde + succinate + CO2
-
 ?
taurine + 2-oxoglutarate + O2 calculations using large cluster models that include key hydrogen bonding interactions in the substrate binding pocket and His70 protonated reproduce experimental rates and selectivity excellently and give a dominant C1-hydroxylation channel leading to R-1-hydroxytaurine products. This is triggered by charged active site residues including a protonated His70 group Escherichia coli sulfite + aminoacetaldehyde + succinate + CO2
-
 ?
taurine + 2-oxoglutarate + O2
-
 Escherichia coli K12 sulfite + aminoacetaldehyde + succinate + CO2
-
 ?
taurine + 2-oxoglutarate + O2 calculations using large cluster models that include key hydrogen bonding interactions in the substrate binding pocket and His70 protonated reproduce experimental rates and selectivity excellently and give a dominant C1-hydroxylation channel leading to R-1-hydroxytaurine products. This is triggered by charged active site residues including a protonated His70 group Escherichia coli K12 sulfite + aminoacetaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
TauD
-
 Escherichia coli
taurine/alpha-ketoglutarate dioxygenase
-
 Escherichia coli