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Literature summary for 1.14.11.17 extracted from

  • Kalliri, E.; Grzyska, P.K.; Hausinger, R.P.
    Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD (2005), Biochem. Biophys. Res. Commun., 338, 191-197.
    View publication on PubMed
Search for more literature for 1.14.11.17

Inhibitors

Inhibitors Comment Organism Structure
Co2+ IC50: 0.0019 mM, in the presence of Fe2+; IC50: 0.041 mM Escherichia coli
N-oxalylglycine
-
 Escherichia coli
Ni2+ IC50: 0.00071 mM, in the presence of Fe2+; IC50: 0.032 mM Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DEAE-Sepharose column chromatography and HP phenyl-Sepharose column chromatography Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
taurine + 2-oxoglutarate + O2
-
 Escherichia coli sulfite + aminoacetaldehyde + succinate + CO2
-
 ?

Synonyms

Synonyms Comment Organism
TauD
-
 Escherichia coli
taurine/alpha-ketoglutarate-dependent dioxygenase
-
 Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.29
-
 N-oxalylglycine
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00071
-
 IC50: 0.00071 mM, in the presence of Fe2+ Escherichia coli Ni2+
0.0019
-
 IC50: 0.0019 mM, in the presence of Fe2+ Escherichia coli Co2+
0.032
-
 IC50: 0.032 mM Escherichia coli Ni2+
0.041
-
 IC50: 0.041 mM Escherichia coli Co2+