Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | required | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide L-asparagine + 2-oxoglutarate + O2 | Homo sapiens | enzyme catalyzes the erythro-beta-hydroxylation of asparaginyl and aspartyl residues to form the 2S, 3R-product, possible role in the Notch signalling pathway | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
peptide L-asparagine + 2-oxoglutarate + O2 | Homo sapiens | hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
peptide L-asparagine + 2-oxoglutarate + O2 | - |
Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
peptide L-asparagine + 2-oxoglutarate + O2 | enzyme catalyzes the erythro-beta-hydroxylation of asparaginyl and aspartyl residues to form the 2S, 3R-product, possible role in the Notch signalling pathway | Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? | |
peptide L-asparagine + 2-oxoglutarate + O2 | hydroxylation of Asn803 in hypoxia-inducible transcription factor, converted protein is incapable in interacting with the transcripitonal coactivator p300 | Homo sapiens | peptide 3-hydroxy-L-asparagine + succinate + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | homodimer, crystal structure analysis | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
EGF beta-hydroxylase | - |
Homo sapiens |
EGFH | - |
Homo sapiens |
factor inhibiting hypoxia-inducible transcription factor (HIF) | - |
Homo sapiens |
FIH | - |
Homo sapiens |
human aspartyl (asparaginyl) beta-hydroxylase | - |
Homo sapiens |