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Literature summary for 1.14.11.11 extracted from
- Production of tropane alkaloids by biotransformation using recombinant Escherichia coli whole cells (2017), Biochem. Eng. J., 125, 180-189 .
No PubMed abstract available
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | tropane alkaloids, such as hyoscyamine, 6-hydroxyhyoscyamine and scopolamine, are secondary metabolites that are traditionally applied in medicine due to their anticholinergic activity. An alternative strategy for the production of the most valuable alkaloids, 6beta-hydroxyhyoscyamine and scopolamine, using Escherichia coli harboring the hyoscyamine-6beta-hydroxylase enzyme as biocatalysts is developed | Brugmansia x candida |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| the h6hcDNA is amplified from Brugmansia candida total RNA preparations, it is inserted in frame to the trx tag into the pET32a(+) vector. Escherichia coli Origami strains are used as host for the expression. Produce of high quantities of a soluble and functional enzyme | Brugmansia x candida |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brugmansia x candida | B2CNC8 | - |
- |
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Release 2023.1 (January 2023)
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