Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.11.11 extracted from

  • Dehghan, E.; Shahriari Ahmadi, F.; Ghotbi Ravandi, E.; Reed, D.W.; Covello, P.S.; Bahrami, A.R.
    An atypical pattern of accumulation of scopolamine and other tropane alkaloids and expression of alkaloid pathway genes in Hyoscyamus senecionis (2013), Plant Physiol. Biochem., 70, 188-194.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene h6h, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, gene expression profiling and real-time RT-PCR analysis Hyoscyamus senecionis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39015
-
x * 39015, sequence calculation Hyoscyamus senecionis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-hyoscyamine + 2-oxoglutarate + O2 Hyoscyamus senecionis
-
(6S)-hydroxyhyoscyamine + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Hyoscyamus senecionis J7HDC2 gene h6h
-

Source Tissue

Source Tissue Comment Organism Textmining
flower
-
Hyoscyamus senecionis
-
leaf
-
Hyoscyamus senecionis
-
additional information H6H tissue expression analysis, overview Hyoscyamus senecionis
-
rhizome
-
Hyoscyamus senecionis
-
root
-
Hyoscyamus senecionis
-
stem
-
Hyoscyamus senecionis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-hyoscyamine + 2-oxoglutarate + O2
-
Hyoscyamus senecionis (6S)-hydroxyhyoscyamine + succinate + CO2
-
?
additional information the enzyme also catalyzes the reaction of EC 1.14.11.14 Hyoscyamus senecionis ?
-
?

Subunits

Subunits Comment Organism
? x * 39015, sequence calculation Hyoscyamus senecionis

Synonyms

Synonyms Comment Organism
H6H
-
Hyoscyamus senecionis
hyoscyamine 6beta-hydroxylase
-
Hyoscyamus senecionis

pI Value

Organism Comment pI Value Maximum pI Value
Hyoscyamus senecionis sequence calculation
-
5.08

General Information

General Information Comment Organism
evolution the enzyme belongs to the 2-oxoglutarate-depedent dioxygenase family Hyoscyamus senecionis
metabolism the enzyme catalyzes the last two steps in the scopolamine biosynthetic pathway performing two consecutive oxidation reactions including the hydroxylation of hyoscyamine to 6beta-hydroxyhyoscyamine and the epoxidation of 6beta-hydroxyhyoscyamine to yield scopolamine. Biosynthesis pathway of tropane alkaloids, overview Hyoscyamus senecionis