Cloned (Comment) | Organism |
---|---|
gene h6h, DNA and amino acid sequence determination and analysis, sequence comparisons and phylogenetic tree, gene expression profiling and real-time RT-PCR analysis | Hyoscyamus senecionis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39015 | - |
x * 39015, sequence calculation | Hyoscyamus senecionis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-hyoscyamine + 2-oxoglutarate + O2 | Hyoscyamus senecionis | - |
(6S)-hydroxyhyoscyamine + succinate + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Hyoscyamus senecionis | J7HDC2 | gene h6h | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
flower | - |
Hyoscyamus senecionis | - |
leaf | - |
Hyoscyamus senecionis | - |
additional information | H6H tissue expression analysis, overview | Hyoscyamus senecionis | - |
rhizome | - |
Hyoscyamus senecionis | - |
root | - |
Hyoscyamus senecionis | - |
stem | - |
Hyoscyamus senecionis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-hyoscyamine + 2-oxoglutarate + O2 | - |
Hyoscyamus senecionis | (6S)-hydroxyhyoscyamine + succinate + CO2 | - |
? | |
additional information | the enzyme also catalyzes the reaction of EC 1.14.11.14 | Hyoscyamus senecionis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 39015, sequence calculation | Hyoscyamus senecionis |
Synonyms | Comment | Organism |
---|---|---|
H6H | - |
Hyoscyamus senecionis |
hyoscyamine 6beta-hydroxylase | - |
Hyoscyamus senecionis |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Hyoscyamus senecionis | sequence calculation | - |
5.08 |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to the 2-oxoglutarate-depedent dioxygenase family | Hyoscyamus senecionis |
metabolism | the enzyme catalyzes the last two steps in the scopolamine biosynthetic pathway performing two consecutive oxidation reactions including the hydroxylation of hyoscyamine to 6beta-hydroxyhyoscyamine and the epoxidation of 6beta-hydroxyhyoscyamine to yield scopolamine. Biosynthesis pathway of tropane alkaloids, overview | Hyoscyamus senecionis |