BRENDA - Enzyme Database show
show all sequences of 1.13.99.1

myo-Inositol oxygenase overexpression accentuates generation of reactive oxygen species and exacerbates cellular injury following high glucose ambience a new mechanism relevant to the pathogenesis of diabetic nephropathy

Sun, L.; Dutta, R.K.; Xie, P.; Kanwar, Y.S.; J. Biol. Chem. 291, 5688-5707 (2016)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
gene MIOX, quantitative real-time PCR enzyme expression analysis, overexpression of MIOX in LLC-PK1 cells boosts the generation of H2O2
Sus scrofa
Engineering
Amino acid exchange
Commentary
Organism
additional information
under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA, overview. Cells under high glucose ambience or transfected with MIOX-pcDNA show increased expression of apoptogenic protein Bax. The expression is further increased following concomitant treatment with HG and MIOX transfection. Treatment with N-acetylcysteine reduces the expression of Bax
Sus scrofa
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Sus scrofa
-
D-glucuronate + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Sus scrofa
Q8WN98
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
LLC-PK1 cell
-
Sus scrofa
-
additional information
immunohistochemic analysis
Sus scrofa
-
renal tubule
MIOX is a tubular-specific enzyme
Sus scrofa
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
745357
Sus scrofa
D-glucuronate + H2O
-
-
-
?
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Sus scrofa
Cloned(Commentary) (protein specific)
Commentary
Organism
gene MIOX, quantitative real-time PCR enzyme expression analysis, overexpression of MIOX in LLC-PK1 cells boosts the generation of H2O2
Sus scrofa
Engineering (protein specific)
Amino acid exchange
Commentary
Organism
additional information
under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA, overview. Cells under high glucose ambience or transfected with MIOX-pcDNA show increased expression of apoptogenic protein Bax. The expression is further increased following concomitant treatment with HG and MIOX transfection. Treatment with N-acetylcysteine reduces the expression of Bax
Sus scrofa
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Sus scrofa
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Sus scrofa
-
D-glucuronate + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
LLC-PK1 cell
-
Sus scrofa
-
additional information
immunohistochemic analysis
Sus scrofa
-
renal tubule
MIOX is a tubular-specific enzyme
Sus scrofa
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
745357
Sus scrofa
D-glucuronate + H2O
-
-
-
?
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
37
-
assay at
Sus scrofa
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
8
-
assay at
Sus scrofa
Expression
Organism
Commentary
Expression
Sus scrofa
the enzyme expression is upregulated under high glucose treatment in LLC-PK1 cells, a tubular cell line. Under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA, overview
up
General Information
General Information
Commentary
Organism
malfunction
following increased expression of MIOX in tubular cells under high glucose ambience, there is an accentuated perturbation in cellular redox and mitochondrial homeostasis, leading to cellular apoptosis. In addition, there is an increased synthesis of extracellular matrix proteins, reflective of tubulo-interstitial injury in diabetic nephropathy; under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA
Sus scrofa
physiological function
myo-inositol oxygenase (MIOX) is a tubular enzyme that catabolizes myo-inositol to D-glucuronate via the glucuronate-xylulose pathway
Sus scrofa
General Information (protein specific)
General Information
Commentary
Organism
malfunction
following increased expression of MIOX in tubular cells under high glucose ambience, there is an accentuated perturbation in cellular redox and mitochondrial homeostasis, leading to cellular apoptosis. In addition, there is an increased synthesis of extracellular matrix proteins, reflective of tubulo-interstitial injury in diabetic nephropathy; under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA
Sus scrofa
physiological function
myo-inositol oxygenase (MIOX) is a tubular enzyme that catabolizes myo-inositol to D-glucuronate via the glucuronate-xylulose pathway
Sus scrofa
Expression (protein specific)
Organism
Commentary
Expression
Sus scrofa
the enzyme expression is upregulated under high glucose treatment in LLC-PK1 cells, a tubular cell line. Under high-glucose ambience, MIOX overexpression accentuates redox imbalance, perturbed NAD+/NADH ratios, increased ROS generation, depleted reduced glutathione, reduced GSH/GSSG ratio, and enhanced adaptive changes in the profile of the antioxidant defense system. These changes are also accompanied by mitochondrial dysfunctions, DNA damage and induction of apoptosis, accentuated activity of profibrogenic cytokine, and expression of fibronectin, the latter two being the major hallmarks of diabetic nephropathy. These perturbations are largely blocked by various reactive oxygen species inhibitors (Mito Q, diphenyleneiodonium chloride, and N-acetylcysteine) and MIOX/NOX4 siRNA, overview
up
Other publictions for EC 1.13.99.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745009
Shi
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2
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1
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745343
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291
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14
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5
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4
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8
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8
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745357
Sun
myo-Inositol oxygenase overex ...
Sus scrofa
J. Biol. Chem.
291
5688-5707
2016
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1
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1
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1
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1
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1
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1
2
2
1
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745184
Zhan
Disruption of renal tubular m ...
Homo sapiens, Mus musculus
J. Am. Soc. Nephrol.
26
1304-1321
2015
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2
2
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2
6
6
2
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746190
Chen
Ectopic expression of a Glyci ...
Arabidopsis thaliana, Glycine soja 07256, Glycine soja
PLoS ONE
10
e0129998
2015
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2
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1
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1
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1
1
3
3
1
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728381
Siddique
Myo-inositol oxygenase is impo ...
Arabidopsis thaliana
New Phytol.
201
476-85
2014
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1
2
2
1
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744739
Gaut
Development of an immunoassay ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Clin. Chem.
60
747-757
2014
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1
1
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2
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745898
Siddique
Myo-inositol oxygenase is imp ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
New Phytol.
201
476-485
2014
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14
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8
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1
2
8
4
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727646
Senthilraja
-
Computational screening and do ...
Homo sapiens
Int. J. Pharm. Sci. Rev. Res.
20
158-161
2013
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6
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727579
Alford
myo-Inositol oxygenase is requ ...
Arabidopsis thaliana
Front. Plant Sci.
3
69
2012
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727881
Nayak
Transcriptional and post-trans ...
Mus musculus
J. Biol. Chem.
286
27594-27611
2011
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712593
Yang
Polymorphisms of myo-inositol ...
Homo sapiens
J. Diabetes Complicat.
24
404-408
2010
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2
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2
2
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695783
Moon
Production of glucaric acid fr ...
Mus musculus
Appl. Environ. Microbiol.
75
589-595
2009
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5
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697532
Bollinger
myo-Inositol oxygenase: a radi ...
Mammalia, Mus musculus
Dalton Trans.
2009
905-914
2009
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697793
Lu
Increased expression of myo-in ...
Rattus norvegicus
Exp. Clin. Endocrinol. Diabetes
117
257-265
2009
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700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
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5
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9
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700818
Endres
Myoinositol oxygenase controls ...
Arabidopsis thaliana
Plant Physiol.
149
1042-1049
2009
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687712
Thorsell
Structural and biophysical cha ...
Homo sapiens
J. Biol. Chem.
283
15209-15216
2008
-
-
-
1
-
-
-
-
-
1
-
-
-
2
-
-
-
1
-
-
-
-
-
-
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-
-
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-
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-
-
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-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671152
Brown
Purification, crystallization ...
Mus musculus
Acta Crystallogr. Sect. F
F62
811-813
2006
1
-
1
1
-
-
-
-
-
1
1
-
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671732
Arner
Expression of myo-inositol oxy ...
Homo sapiens, Mus musculus, Sus scrofa
Biochem. Biophys. Res. Commun.
339
816-820
2006
-
-
-
-
-
-
-
-
-
-
3
-
-
5
-
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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3
-
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-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672163
Xing
A coupled dinuclear iron clust ...
Mus musculus
Biochemistry
45
5393-5401
2006
-
-
1
-
-
-
-
-
-
1
1
-
-
2
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
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-
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1
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1
1
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1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672164
Xing
Oxygen activation by a mixed-v ...
Mus musculus
Biochemistry
45
5402-5412
2006
1
-
1
-
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
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-
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1
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-
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1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
674174
Kim
Demonstration by 2H ENDOR spec ...
Mus musculus
J. Am. Chem. Soc.
128
10374-10375
2006
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676819
Brown
Crystal structure of a substra ...
Mus musculus
Proc. Natl. Acad. Sci. USA
103
15032-15037
2006
1
-
1
1
-
-
-
-
-
1
-
-
-
2
-
-
1
-
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676860
Xing
Evidence for C-H cleavage by a ...
Mus musculus
Proc. Natl. Acad. Sci. USA
103
6130-6135
2006
-
-
1
-
-
-
-
-
-
1
-
-
-
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
659474
Prabhu
Up-regulation of human myo-ino ...
Homo sapiens
J. Biol. Chem.
280
19895-19901
2005
-
-
1
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
3
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676686
Kanter
The inositol oxygenase gene fa ...
Arabidopsis thaliana
Planta
221
243-254
2005
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
676782
Nayak
Modulation of renal-specific o ...
Mus musculus
Proc. Natl. Acad. Sci. USA
102
17952-17957
2005
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
657777
Arner
Molecular cloning, expression, ...
Homo sapiens, Mus musculus, Rattus norvegicus
Biochem. Biophys. Res. Commun.
324
1386-1392
2004
-
-
3
-
-
3
-
6
-
-
3
3
-
7
-
-
3
-
-
6
-
-
6
3
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
3
-
-
-
6
-
-
3
3
-
-
-
3
-
6
-
-
6
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660234
Lorence
myo-Inositol oxygenase offers ...
Arabidopsis thaliana
Plant Physiol.
134
1200-1205
2004
-
-
1
-
-
-
-
-
-
1
-
1
-
3
-
-
1
-
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
3
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
660561
Kanter
Purification, characterization ...
Sporopachydermia lactativora
Yeast
20
1317-1329
2003
-
-
1
-
-
-
2
2
-
-
2
1
-
7
-
-
1
-
-
-
-
-
1
1
1
1
-
-
1
1
-
-
2
-
-
-
-
1
-
-
-
-
-
2
2
2
-
-
2
1
-
-
-
1
-
-
-
-
1
1
1
1
-
-
1
1
-
-
-
-
-
-
-
-
172313
Arner
myo-Inositol oxygenase: molecu ...
Sus scrofa
Biochem. J.
360
313-320
2001
1
-
1
-
-
-
-
1
-
1
1
1
-
2
-
-
1
-
-
1
-
-
3
1
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
1
1
-
-
-
1
-
1
-
-
3
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
6873
Koller
myo-inositol oxygenase from ra ...
Rattus norvegicus
Eur. J. Biochem.
193
421-427
1990
-
-
-
-
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6875
Naber
L-myo-Inosose-1 as a probable ...
Sus scrofa
Biochemistry
25
7201-7207
1986
-
-
-
-
-
2
4
1
-
1
-
-
-
1
2
-
-
-
-
1
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
2
-
4
-
1
-
1
-
-
-
2
-
-
-
1
-
1
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
6872
Graham
-
Partial purification of myo-in ...
Bos taurus
Biochem. Soc. Trans.
13
481
1985
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
1
-
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
2
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
6871
Koller
Affinity chromatography of myo ...
Rattus norvegicus
J. Chromatogr.
283
191-197
1984
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6867
Moskala
An oxygen-18 tracer investigat ...
Sus scrofa
Biochem. Biophys. Res. Commun.
99
107-113
1981
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6868
Reddy
Activation of homogeneous prep ...
Sus scrofa
Biochem. Biophys. Res. Commun.
100
1389-1395
1981
4
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6869
Reddy
myo-Inositol oxygenase from ho ...
Sus scrofa
J. Biol. Chem.
156
8510-8518
1981
-
-
-
-
-
-
-
-
-
1
1
-
-
1
-
-
1
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
6874
Reddy
myo-Inositol oxygenase from ho ...
Sus scrofa
J. Biol. Chem.
256
8519-8524
1981
4
-
-
-
-
-
31
2
-
1
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
4
-
-
-
-
-
-
-
31
-
2
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
6870
Koller
myo-Inositol oxygenase from ra ...
Rattus norvegicus
Hoppe-Seyler's Z. Physiol. Chem.
360
507-513
1979
-
-
-
-
-
-
2
2
-
1
1
-
-
2
1
-
1
-
-
2
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
2
-
1
1
-
-
1
-
1
-
2
1
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
6866
Charalampous
Biochemical studies on inosito ...
Rattus norvegicus
J. Biol. Chem.
234
220-227
1959
2
-
-
-
-
-
28
1
-
1
-
-
-
1
-
-
1
-
-
1
-
2
1
-
1
-
-
1
1
1
-
1
-
-
-
2
-
-
1
-
-
-
-
28
-
1
-
1
-
-
-
-
-
1
-
1
-
2
1
-
1
-
-
1
1
1
-
-
-
-
-
-
-
-