BRENDA - Enzyme Database show
show all sequences of 1.13.99.1

Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease

Zhan, M.; Usman, I.M.; Sun, L.; Kanwar, Y.S.; J. Am. Soc. Nephrol. 26, 1304-1321 (2015)

Data extracted from this reference:

Application
Application
Commentary
Organism
medicine
the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease
Homo sapiens
medicine
the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease
Mus musculus
Cloned(Commentary)
Commentary
Organism
gene MIOX, quantitative enzyme expression analysis
Homo sapiens
gene MIOX, quantitative enzyme expression analysis
Mus musculus
Inhibitors
Inhibitors
Commentary
Organism
Structure
D-glucarate
a MIOX inhibitor
Homo sapiens
D-glucarate
a MIOX inhibitor, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice
Mus musculus
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Mus musculus
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Homo sapiens
-
D-glucuronate + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9UGB7
-
-
Mus musculus
Q9QXN5
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
HK-2 cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
kidney
-
Mus musculus
-
renal tubule
MIOX is a tubular-specific enzyme
Homo sapiens
-
renal tubule
MIOX is a tubular-specific enzyme
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
745184
Mus musculus
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
745184
Homo sapiens
D-glucuronate + H2O
-
-
-
?
Application (protein specific)
Application
Commentary
Organism
medicine
the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease
Homo sapiens
medicine
the enzyme is a possible target for treatment of diabetic kidney disease. MIOX enzyme inhibitor D-glucarate might be a potential therapeutic agent for the amelioration of diabetic kidney disease
Mus musculus
Cloned(Commentary) (protein specific)
Commentary
Organism
gene MIOX, quantitative enzyme expression analysis
Homo sapiens
gene MIOX, quantitative enzyme expression analysis
Mus musculus
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
D-glucarate
a MIOX inhibitor
Homo sapiens
D-glucarate
a MIOX inhibitor, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice
Mus musculus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
mitochondrion
-
Homo sapiens
5739
-
mitochondrion
-
Mus musculus
5739
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Mus musculus
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Homo sapiens
-
D-glucuronate + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
HK-2 cell
-
Homo sapiens
-
kidney
-
Homo sapiens
-
kidney
-
Mus musculus
-
renal tubule
MIOX is a tubular-specific enzyme
Homo sapiens
-
renal tubule
MIOX is a tubular-specific enzyme
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
745184
Mus musculus
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
745184
Homo sapiens
D-glucuronate + H2O
-
-
-
?
Expression
Organism
Commentary
Expression
Homo sapiens
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience
up
Mus musculus
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience
up
General Information
General Information
Commentary
Organism
malfunction
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations
Homo sapiens
malfunction
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice
Mus musculus
metabolism
a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease
Homo sapiens
metabolism
a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease
Mus musculus
physiological function
myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview
Homo sapiens
physiological function
myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
malfunction
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations
Homo sapiens
malfunction
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience. Additionally, dysfunctional mitochondria accumulate in the cytoplasm. Decreasing the expression of MIOX under high-glucose ambience increases PTEN-induced putative kinase 1 expression and the dependent mitofusin-2-Parkin interaction. Overexpression of MIOX in the cells enhances the effects of high-glucose, whereas MIOX siRNA or D-glucarate, an inhibitor of MIOX, partially reverse these perturbations, D-glucarate normalizes reduced autophagy and mitophagy in tubules of STZ-induced diabetic mice
Mus musculus
metabolism
a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease
Homo sapiens
metabolism
a mechanism links MIOX to impaired mitochondrial quality control during tubular injury in the pathogenesis of diabetic kidney disease
Mus musculus
physiological function
myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview
Homo sapiens
physiological function
myo-inositol oxygenase (MIOX) is a tubular-specific enzyme, that modulates redox imbalance and apoptosis in tubular cells in diabetes, role of MIOX in perturbation of mitochondrial quality control, including mitochondrial dynamics and autophagy/mitophagy, under high-glucose ambience or a diabetic state, overview
Mus musculus
Expression (protein specific)
Organism
Commentary
Expression
Homo sapiens
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience
up
Mus musculus
upregulation of MIOX accompanied by mitochondrial fragmentation and depolarization, inhibition of autophagy/mitophagy, and altered expression of mitochondrial dynamic and mitophagic proteins under high-glucose ambience
up
Other publictions for EC 1.13.99.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745009
Shi
Overexpression of the PeaT1 e ...
Oryza sativa
Front. Plant Sci.
8
970
2017
-
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1
-
-
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1
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2
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5
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1
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1
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1
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2
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1
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2
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-
-
-
-
-
1
1
1
1
-
-
744811
Liu
Production of glucaric acid f ...
Komagataella phaffii, Komagataella phaffii GS115, Mus musculus
Enzyme Microb. Technol.
91
8-16
2016
-
-
2
-
1
-
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3
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6
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1
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3
-
2
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-
-
2
-
-
-
1
2
2
1
-
-
745343
Tominaga
Transcriptional and translati ...
Homo sapiens, Mus musculus, Mus musculus CD1, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
291
1348-1367
2016
1
-
4
-
-
-
-
-
4
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5
-
6
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14
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5
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4
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4
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1
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4
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4
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5
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14
-
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5
-
4
-
-
-
4
-
-
-
8
-
-
8
-
-
745357
Sun
myo-Inositol oxygenase overex ...
Sus scrofa
J. Biol. Chem.
291
5688-5707
2016
-
-
1
-
1
-
-
-
1
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1
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1
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-
-
4
-
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1
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1
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1
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1
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1
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1
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1
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-
-
4
-
-
1
-
1
-
-
-
1
-
-
-
1
2
2
1
-
-
745184
Zhan
Disruption of renal tubular m ...
Homo sapiens, Mus musculus
J. Am. Soc. Nephrol.
26
1304-1321
2015
-
2
2
-
-
-
2
-
2
-
-
2
-
3
-
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-
-
-
5
-
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2
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2
2
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2
-
-
2
-
-
2
-
-
-
-
-
5
-
-
2
-
-
-
-
-
-
-
-
-
2
6
6
2
-
-
746190
Chen
Ectopic expression of a Glyci ...
Arabidopsis thaliana, Glycine soja 07256, Glycine soja
PLoS ONE
10
e0129998
2015
-
-
2
-
1
-
-
-
-
-
-
3
-
6
-
-
-
-
-
4
-
-
3
1
-
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-
-
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1
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2
-
-
1
-
-
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-
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-
-
-
3
-
-
-
-
-
4
-
-
3
1
-
-
-
-
-
-
-
1
1
3
3
1
-
-
728381
Siddique
Myo-inositol oxygenase is impo ...
Arabidopsis thaliana
New Phytol.
201
476-85
2014
-
-
-
-
-
-
-
-
-
-
-
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5
-
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1
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1
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1
2
2
1
-
-
744739
Gaut
Development of an immunoassay ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Clin. Chem.
60
747-757
2014
-
1
1
-
-
-
-
-
-
-
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3
-
7
-
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-
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8
-
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3
1
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1
1
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3
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8
-
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3
1
-
-
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-
-
-
-
-
-
2
2
-
-
-
745898
Siddique
Myo-inositol oxygenase is imp ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
New Phytol.
201
476-485
2014
-
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1
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1
-
-
-
-
-
-
8
-
12
-
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4
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8
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4
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4
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8
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14
-
-
8
-
-
-
-
-
-
-
-
-
1
2
8
4
-
-
727646
Senthilraja
-
Computational screening and do ...
Homo sapiens
Int. J. Pharm. Sci. Rev. Res.
20
158-161
2013
-
-
-
-
-
-
6
-
-
-
-
-
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1
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727579
Alford
myo-Inositol oxygenase is requ ...
Arabidopsis thaliana
Front. Plant Sci.
3
69
2012
-
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2
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2
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1
1
1
1
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727881
Nayak
Transcriptional and post-trans ...
Mus musculus
J. Biol. Chem.
286
27594-27611
2011
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1
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3
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2
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1
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1
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1
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1
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1
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1
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2
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2
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712593
Yang
Polymorphisms of myo-inositol ...
Homo sapiens
J. Diabetes Complicat.
24
404-408
2010
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1
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2
2
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695783
Moon
Production of glucaric acid fr ...
Mus musculus
Appl. Environ. Microbiol.
75
589-595
2009
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1
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5
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9
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9
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1
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1
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1
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1
1
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-
697532
Bollinger
myo-Inositol oxygenase: a radi ...
Mammalia, Mus musculus
Dalton Trans.
2009
905-914
2009
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2
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2
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2
2
-
-
-
697793
Lu
Increased expression of myo-in ...
Rattus norvegicus
Exp. Clin. Endocrinol. Diabetes
117
257-265
2009
1
-
1
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3
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1
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1
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1
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1
1
1
1
-
-
700488
Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
184
457-472
2009
-
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1
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5
-
-
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9
-
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2
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4
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8
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