BRENDA - Enzyme Database show
show all sequences of 1.13.99.1

Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury

Gaut, J.P.; Crimmins, D.L.; Ohlendorf, M.F.; Lockwood, C.M.; Griest, T.A.; Brada, N.A.; Hoshi, M.; Sato, B.; Hotchkiss, R.S.; Jain, S.; Ladenson, J.H.; Clin. Chem. 60, 747-757 (2014)

Data extracted from this reference:

Application
Application
Commentary
Organism
diagnostics
the kidney-specific protein myo-inositol oxygenase is a potential biomarker of acute kidney injury, AKI
Homo sapiens
Cloned(Commentary)
Commentary
Organism
gene MIOX, kidney-specific expression, recombinant expression of GST-tagged enzyme in HEK-293 cells, cleavage of the GST tag by thrombin
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Mus musculus
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Homo sapiens
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Mus musculus C57BL/6
-
D-glucuronate + H2O
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9UGB7
-
-
Mus musculus
Q9QXN5
-
-
Mus musculus C57BL/6
Q9QXN5
-
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
blood plasma
plasma MIOX is increased in critically ill patients with acute kidney injury compared with patients without acute kidney injury and is highest in patients with oliguric acute kidney injury
Homo sapiens
-
blood plasma
from mice with acute kidney injury, MIOX expression is undetectable in healthy mice plasma
Mus musculus
-
kidney
kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule
Homo sapiens
-
kidney
kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule
Mus musculus
-
additional information
immunohistochemic analysis
Homo sapiens
-
additional information
immunohistochemic analysis
Mus musculus
-
renal proximal tubule
-
Homo sapiens
-
renal proximal tubule
-
Mus musculus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
744739
Mus musculus
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
744739
Homo sapiens
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
744739
Mus musculus C57BL/6
D-glucuronate + H2O
-
-
-
?
Subunits
Subunits
Commentary
Organism
?
x * 37000, recombinant detagged enzyme, SDS-PAGE
Homo sapiens
Application (protein specific)
Application
Commentary
Organism
diagnostics
the kidney-specific protein myo-inositol oxygenase is a potential biomarker of acute kidney injury, AKI
Homo sapiens
Cloned(Commentary) (protein specific)
Commentary
Organism
gene MIOX, kidney-specific expression, recombinant expression of GST-tagged enzyme in HEK-293 cells, cleavage of the GST tag by thrombin
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
myo-inositol + O2
Mus musculus
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Homo sapiens
-
D-glucuronate + H2O
-
-
?
myo-inositol + O2
Mus musculus C57BL/6
-
D-glucuronate + H2O
-
-
?
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
blood plasma
plasma MIOX is increased in critically ill patients with acute kidney injury compared with patients without acute kidney injury and is highest in patients with oliguric acute kidney injury
Homo sapiens
-
blood plasma
from mice with acute kidney injury, MIOX expression is undetectable in healthy mice plasma
Mus musculus
-
kidney
kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule
Homo sapiens
-
kidney
kidney-specific expression of protein myo-inositol oxygenase encoding gene miox in proximal renal tubule
Mus musculus
-
additional information
immunohistochemic analysis
Homo sapiens
-
additional information
immunohistochemic analysis
Mus musculus
-
renal proximal tubule
-
Homo sapiens
-
renal proximal tubule
-
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
myo-inositol + O2
-
744739
Mus musculus
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
744739
Homo sapiens
D-glucuronate + H2O
-
-
-
?
myo-inositol + O2
-
744739
Mus musculus C57BL/6
D-glucuronate + H2O
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
?
x * 37000, recombinant detagged enzyme, SDS-PAGE
Homo sapiens
General Information
General Information
Commentary
Organism
physiological function
MIOX is a renal specific, proximal tubule protein that is increased in plasma ofanimals and critically ill patients with acute kidney injury, AKI. MIOX preceds the elevation in SCr by approximately two days in human patients
Homo sapiens
physiological function
kidney-specific expression of myo-inositol oxygenase in acute kidney injury
Mus musculus
General Information (protein specific)
General Information
Commentary
Organism
physiological function
MIOX is a renal specific, proximal tubule protein that is increased in plasma ofanimals and critically ill patients with acute kidney injury, AKI. MIOX preceds the elevation in SCr by approximately two days in human patients
Homo sapiens
physiological function
kidney-specific expression of myo-inositol oxygenase in acute kidney injury
Mus musculus
Other publictions for EC 1.13.99.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
745009
Shi
Overexpression of the PeaT1 e ...
Oryza sativa
Front. Plant Sci.
8
970
2017
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1
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1
1
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744811
Liu
Production of glucaric acid f ...
Komagataella phaffii, Komagataella phaffii GS115, Mus musculus
Enzyme Microb. Technol.
91
8-16
2016
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745343
Tominaga
Transcriptional and translati ...
Homo sapiens, Mus musculus, Mus musculus CD1, Rattus norvegicus, Sus scrofa
J. Biol. Chem.
291
1348-1367
2016
1
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14
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8
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745357
Sun
myo-Inositol oxygenase overex ...
Sus scrofa
J. Biol. Chem.
291
5688-5707
2016
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1
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1
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2
2
1
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745184
Zhan
Disruption of renal tubular m ...
Homo sapiens, Mus musculus
J. Am. Soc. Nephrol.
26
1304-1321
2015
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2
2
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2
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2
6
6
2
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746190
Chen
Ectopic expression of a Glyci ...
Arabidopsis thaliana, Glycine soja 07256, Glycine soja
PLoS ONE
10
e0129998
2015
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3
1
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728381
Siddique
Myo-inositol oxygenase is impo ...
Arabidopsis thaliana
New Phytol.
201
476-85
2014
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744739
Gaut
Development of an immunoassay ...
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Clin. Chem.
60
747-757
2014
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1
1
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2
2
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745898
Siddique
Myo-inositol oxygenase is imp ...
Arabidopsis thaliana, Arabidopsis thaliana Col-0
New Phytol.
201
476-485
2014
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1
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1
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8
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12
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14
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8
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1
2
8
4
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727646
Senthilraja
-
Computational screening and do ...
Homo sapiens
Int. J. Pharm. Sci. Rev. Res.
20
158-161
2013
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6
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727579
Alford
myo-Inositol oxygenase is requ ...
Arabidopsis thaliana
Front. Plant Sci.
3
69
2012
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727881
Nayak
Transcriptional and post-trans ...
Mus musculus
J. Biol. Chem.
286
27594-27611
2011
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712593
Yang
Polymorphisms of myo-inositol ...
Homo sapiens
J. Diabetes Complicat.
24
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2010
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695783
Moon
Production of glucaric acid fr ...
Mus musculus
Appl. Environ. Microbiol.
75
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2009
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697532
Bollinger
myo-Inositol oxygenase: a radi ...
Mammalia, Mus musculus
Dalton Trans.
2009
905-914
2009
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Increased expression of myo-in ...
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Exp. Clin. Endocrinol. Diabetes
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Siddique
Myo-inositol oxygenase genes a ...
Arabidopsis thaliana
New Phytol.
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2009
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700818
Endres
Myoinositol oxygenase controls ...
Arabidopsis thaliana
Plant Physiol.
149
1042-1049
2009
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687712
Thorsell
Structural and biophysical cha ...
Homo sapiens
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283
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2008
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671152
Brown
Purification, crystallization ...
Mus musculus
Acta Crystallogr. Sect. F
F62
811-813
2006
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