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Literature summary for 1.13.99.1 extracted from

  • Reddy, C.C.; Pierzchala, P.A.; Hamilton, G.A.
    myo-Inositol oxygenase from hog kidney. II. Catalytic properties of the homogeneous enzyme (1981), J. Biol. Chem., 256, 8519-8524.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine Sus scrofa
cysteine DL-penicillamine Sus scrofa
cysteine either reagent alone gives very little activation Sus scrofa
cysteine L-cysteine can be replaced by D-cysteine Sus scrofa
cysteine or gamma-L-glutamyl-L-cysteine Sus scrofa
D-cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa
DL-Penicillamine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa
gamma-L-glutamyl-L-cysteine best activation system: 1 mM Fe(II) and 2 mM cysteine, L-cysteine can be replaced by D-cysteine, DL-penicillamine or gamma-L-glutamyl-L-cysteine Sus scrofa

Inhibitors

Inhibitors Comment Organism Structure
5,5'-dithiobis(2-nitrobenzoate)
-
Sus scrofa
8-hydroxyquinoline
-
Sus scrofa
ADP
-
Sus scrofa
alpha,alpha'-bipyridine
-
Sus scrofa
alpha-ketoglutarate
-
Sus scrofa
ATP
-
Sus scrofa
azide
-
Sus scrofa
Barbital
-
Sus scrofa
Cu2+
-
Sus scrofa
cyanide
-
Sus scrofa
diethyldithiocarbamate
-
Sus scrofa
EDTA
-
Sus scrofa
Fe3+
-
Sus scrofa
ferricyanide
-
Sus scrofa
ferrocyanide
-
Sus scrofa
glyoxylate
-
Sus scrofa
GTP
-
Sus scrofa
H2O2
-
Sus scrofa
Hg2+
-
Sus scrofa
iodoacetate
-
Sus scrofa
N-ethylmaleimide slight Sus scrofa
o-phenanthroline
-
Sus scrofa
oxalacetate
-
Sus scrofa
oxalate
-
Sus scrofa
p-chloromercuribenzoate
-
Sus scrofa
Phenobarbital
-
Sus scrofa
pyruvate
-
Sus scrofa
Sodium borohydride
-
Sus scrofa
UDP
-
Sus scrofa
UTP
-
Sus scrofa
xanthurenic acid
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.2
-
Inositol with Fe(II) and quinolinic acid as activators Sus scrofa
5
-
Inositol with Fe(II) and L-cysteine as activators Sus scrofa

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ either reagent alone gives very little activation Sus scrofa
Fe2+ no other metal ion can replace Fe(II) Sus scrofa
Fe2+ 1 mM Fe(II) and 2 mM cysteine Sus scrofa

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
myo-inositol + O2 highly specific for myo-inositol Sus scrofa D-glucuronate + H2O
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
34
-
inactivation during 15 min assay Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Sus scrofa