Literature summary for 1.13.12.7 extracted from

Auld, D.S.; Zhang, Y.Q.; Southall, N.T.; Rai, G.; Landsman, M.; Maclure, J.; Langevin, D.; Thomas, C.J.; Austin, C.P.; Inglese, J.
A basis for reduced chemical library inhibition of firefly luciferase obtained from directed evolution (2009), J. Med. Chem., 52, 1450-1458.

Search for more literature for 1.13.12.7

Inhibitors

Inhibitors	Comment	Organism
2-(2-chlorophenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(2-chlorophenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(2-methoxyphenyl)-1,3-benzothiazole	-	Photinus pyralis
2-(2-methoxyphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
2-(3,4-dimethoxyphenyl)-1,3-benzothiazole	-	Photinus pyralis
2-(3,4-dimethoxyphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
2-(3,4-dimethoxyphenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(3,4-dimethoxyphenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(3-fluorophenyl)-1,3-benzothiazole	-	Photinus pyralis
2-(3-fluorophenyl)-1,3-benzothiazole	-	Photuris pensylvanica
2-(3-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(3-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(4-chlorophenyl)-1,3-benzothiazole	-	Photinus pyralis
2-(4-chlorophenyl)-1,3-benzothiazole	-	Photuris pensylvanica
2-(4-chlorophenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(4-chlorophenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(4-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photinus pyralis
2-(4-fluorophenyl)-6-methoxy-1,3-benzothiazole	-	Photuris pensylvanica
2-(4-methoxyphenyl)-1,3-benzothiazole	-	Photinus pyralis
2-(4-methoxyphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photinus pyralis
2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photuris pensylvanica
2-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photinus pyralis
2-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photuris pensylvanica
2-(5-pyridin-4-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photinus pyralis
2-(5-pyridin-4-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photuris pensylvanica
2-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine	-	Photinus pyralis
2-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine	-	Photuris pensylvanica
3-(2-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole	-	Photinus pyralis
3-(2-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole	-	Photuris pensylvanica
3-methyl-2-[(E)-phenyldiazenyl]phenol	-	Photinus pyralis
3-methyl-2-[(E)-phenyldiazenyl]phenol	-	Photuris pensylvanica
3-pyridin-2-yl-1,2,4-oxadiazol-5-yl biphenyl-4-carboxylate	-	Photinus pyralis
3-pyridin-2-yl-1,2,4-oxadiazol-5-yl biphenyl-4-carboxylate	-	Photuris pensylvanica
4-(1,3-benzothiazol-2-yl)-N,N-dimethylaniline	-	Photinus pyralis
4-(1,3-benzothiazol-2-yl)-N,N-dimethylaniline	-	Photuris pensylvanica
4-(1,3-benzothiazol-2-yl)benzonitrile	-	Photinus pyralis
4-(1,3-benzothiazol-2-yl)benzonitrile	-	Photuris pensylvanica
4-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photinus pyralis
4-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine	-	Photuris pensylvanica
4-(6-methoxy-1,3-benzothiazol-2-yl)-N,N-dimethylaniline	-	Photinus pyralis
4-(6-methoxy-1,3-benzothiazol-2-yl)-N,N-dimethylaniline	-	Photuris pensylvanica
4-(6-methoxy-1,3-benzothiazol-2-yl)benzonitrile	-	Photinus pyralis
4-(6-methoxy-1,3-benzothiazol-2-yl)benzonitrile	-	Photuris pensylvanica
4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine	-	Photinus pyralis
4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine	-	Photuris pensylvanica
4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]-N,N-dimethylaniline	-	Photinus pyralis
4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]-N,N-dimethylaniline	-	Photuris pensylvanica
5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole	-	Photinus pyralis
5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole	-	Photuris pensylvanica
5-(2-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole	-	Photinus pyralis
5-(2-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole	-	Photuris pensylvanica
5-(4-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole	-	Photinus pyralis
5-(4-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole	-	Photuris pensylvanica
6-methoxy-2-(2-methoxyphenyl)-1,3-benzothiazole	-	Photinus pyralis
6-methoxy-2-(2-methoxyphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
6-methoxy-2-(3-methylphenyl)-1,3-benzothiazole	-	Photinus pyralis
6-methoxy-2-(3-methylphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
6-methoxy-2-(4-methoxyphenyl)-1,3-benzothiazole	-	Photinus pyralis
6-methoxy-2-(4-methoxyphenyl)-1,3-benzothiazole	-	Photuris pensylvanica
6-methoxy-2-[2-(2-methylbenzyl)phenyl]-1,3-benzothiazole	-	Photinus pyralis
6-methoxy-2-[2-(2-methylbenzyl)phenyl]-1,3-benzothiazole	-	Photuris pensylvanica
6-methoxy-2-[3-(2-methylbenzyl)phenyl]-1,3-benzothiazole	-	Photinus pyralis
6-methoxy-2-[3-(2-methylbenzyl)phenyl]-1,3-benzothiazole	-	Photuris pensylvanica
N-[3-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]acetamide	-	Photinus pyralis
N-[3-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]acetamide	-	Photuris pensylvanica
N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamide	-	Photinus pyralis
N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamide	-	Photuris pensylvanica

Organism

Organism	UniProt	Comment	Textmining
Photinus pyralis	-	-	-
Photuris pensylvanica	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Photinus pyralis
-	Photuris pensylvanica

Synonyms

Synonyms	Comment	Organism
firefly luciferase	-	Photinus pyralis
firefly luciferase	-	Photuris pensylvanica
lucPpe	-	Photuris pensylvanica
lucPpy	-	Photinus pyralis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Photinus pyralis
7.2	-	assay at	Photuris pensylvanica

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor
0.000038	-	-	Photuris pensylvanica	2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine
0.00004	-	-	Photuris pensylvanica	3-pyridin-2-yl-1,2,4-oxadiazol-5-yl biphenyl-4-carboxylate
0.000054	-	-	Photuris pensylvanica	5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole
0.00008	-	-	Photinus pyralis	2-(5-biphenyl-4-yl-1,2,4-oxadiazol-3-yl)pyridine
0.00008	-	-	Photuris pensylvanica	2-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine
0.0002	-	-	Photinus pyralis	5-(2,4-dimethoxyphenyl)-3-phenyl-1,2,4-oxadiazole
0.0002	-	-	Photinus pyralis	4-(1,3-benzothiazol-2-yl)-N,N-dimethylaniline
0.0003	-	-	Photuris pensylvanica	5-(2-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole
0.00032	-	-	Photuris pensylvanica	4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]-N,N-dimethylaniline
0.00032	-	-	Photuris pensylvanica	4-(1,3-benzothiazol-2-yl)-N,N-dimethylaniline
0.00036	-	-	Photuris pensylvanica	2-(4-methoxyphenyl)-1,3-benzothiazole
0.0005	-	-	Photinus pyralis	4-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]-N,N-dimethylaniline
0.0005	-	-	Photuris pensylvanica	2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.00058	-	-	Photuris pensylvanica	5-(4-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole
0.0006	-	-	Photuris pensylvanica	3-(2-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole
0.0006	-	-	Photinus pyralis	2-(2-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.00067	-	-	Photuris pensylvanica	6-methoxy-2-(3-methylphenyl)-1,3-benzothiazole
0.0007	-	-	Photinus pyralis	4-(6-methoxy-1,3-benzothiazol-2-yl)-N,N-dimethylaniline
0.00086	-	-	Photuris pensylvanica	2-(4-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.001	-	-	Photinus pyralis	2-(4-methoxyphenyl)-1,3-benzothiazole
0.0011	-	-	Photuris pensylvanica	2-(3-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.0013	-	-	Photuris pensylvanica	2-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0013	-	-	Photinus pyralis	2-(4-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.0014	-	-	Photinus pyralis	3-pyridin-2-yl-1,2,4-oxadiazol-5-yl biphenyl-4-carboxylate
0.0014	-	-	Photuris pensylvanica	2-(4-chlorophenyl)-1,3-benzothiazole
0.0015	-	-	Photinus pyralis	2-(3-fluorophenyl)-6-methoxy-1,3-benzothiazole
0.0015	-	-	Photinus pyralis	6-methoxy-2-(3-methylphenyl)-1,3-benzothiazole
0.0017	-	-	Photinus pyralis	5-(4-fluorophenyl)-3-(3-methylphenyl)-1,2,4-oxadiazole
0.0019	-	-	Photuris pensylvanica	2-(5-pyridin-4-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0019	-	-	Photuris pensylvanica	N-[3-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]acetamide
0.0019	-	-	Photuris pensylvanica	2-(3,4-dimethoxyphenyl)-1,3-benzothiazole
0.0021	-	-	Photuris pensylvanica	4-(1,3-benzothiazol-2-yl)benzonitrile
0.0022	-	-	Photinus pyralis	6-methoxy-2-(4-methoxyphenyl)-1,3-benzothiazole
0.0024	-	-	Photuris pensylvanica	4-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0027	-	-	Photuris pensylvanica	4-(6-methoxy-1,3-benzothiazol-2-yl)-N,N-dimethylaniline
0.0028	-	-	Photinus pyralis	2-[5-(2-methoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridine
0.0028	-	-	Photinus pyralis	5-(2-fluorophenyl)-3-(4-methoxyphenyl)-1,2,4-oxadiazole
0.0028	-	-	Photinus pyralis	2-(3,4-dimethoxyphenyl)-6-methoxy-1,3-benzothiazole
0.0029	-	-	Photinus pyralis	N-[3-(6-methoxy-1,3-benzothiazol-2-yl)phenyl]acetamide
0.003	-	-	Photinus pyralis	N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamide
0.0031	-	-	Photuris pensylvanica	N-[4-(1,3-benzothiazol-2-yl)phenyl]acetamide
0.0032	-	-	Photinus pyralis	6-methoxy-2-(2-methoxyphenyl)-1,3-benzothiazole
0.0032	-	-	Photinus pyralis	2-(3,4-dimethoxyphenyl)-1,3-benzothiazole
0.0035	-	-	Photinus pyralis	2-(4-chlorophenyl)-6-methoxy-1,3-benzothiazole
0.0038	-	-	Photuris pensylvanica	2-(4-chlorophenyl)-6-methoxy-1,3-benzothiazole
0.0038	-	-	Photuris pensylvanica	2-(3,4-dimethoxyphenyl)-6-methoxy-1,3-benzothiazole
0.0041	-	-	Photuris pensylvanica	6-methoxy-2-(4-methoxyphenyl)-1,3-benzothiazole
0.0043	-	-	Photuris pensylvanica	6-methoxy-2-[2-(2-methylbenzyl)phenyl]-1,3-benzothiazole
0.0045	-	-	Photinus pyralis	2-(4-chlorophenyl)-1,3-benzothiazole
0.0048	-	-	Photuris pensylvanica	4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine
0.0049	-	-	Photuris pensylvanica	2-(2-chlorophenyl)-6-methoxy-1,3-benzothiazole
0.0054	-	-	Photinus pyralis	2-(2-chlorophenyl)-6-methoxy-1,3-benzothiazole
0.0056	-	-	Photuris pensylvanica	6-methoxy-2-(2-methoxyphenyl)-1,3-benzothiazole
0.0057	-	-	Photinus pyralis	4-(6-methoxy-1,3-benzothiazol-2-yl)benzonitrile
0.0061	-	-	Photuris pensylvanica	4-(6-methoxy-1,3-benzothiazol-2-yl)benzonitrile
0.0063	-	-	Photinus pyralis	4-(1,3-benzothiazol-2-yl)benzonitrile
0.0077	-	-	Photuris pensylvanica	2-(2-methoxyphenyl)-1,3-benzothiazole
0.0078	-	-	Photuris pensylvanica	2-(3-fluorophenyl)-1,3-benzothiazole
0.0083	-	-	Photinus pyralis	3-(2-methoxyphenyl)-5-phenyl-1,2,4-oxadiazole
0.0089	-	-	Photinus pyralis	6-methoxy-2-[2-(2-methylbenzyl)phenyl]-1,3-benzothiazole
0.0113	-	-	Photinus pyralis	2-(2-methoxyphenyl)-1,3-benzothiazole
0.0134	-	-	Photinus pyralis	6-methoxy-2-[3-(2-methylbenzyl)phenyl]-1,3-benzothiazole
0.0144	-	-	Photinus pyralis	2-(5-pyridin-4-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0171	-	-	Photinus pyralis	2-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine
0.024	-	-	Photinus pyralis	4-[3-(2-methoxyphenyl)-1,2,4-oxadiazol-5-yl]pyridine
0.024	-	-	Photinus pyralis	4-(5-furan-2-yl-1,2,4-oxadiazol-3-yl)pyridine
0.0242	-	-	Photinus pyralis	2-(3-fluorophenyl)-1,3-benzothiazole
0.03	-	-	Photuris pensylvanica	6-methoxy-2-[3-(2-methylbenzyl)phenyl]-1,3-benzothiazole