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Literature summary for 1.13.12.5 extracted from

  • Woo, J.; Howell, M.H.; von Arnim, A.G.
    Structure-function studies on the active site of the coelenterazine-dependent luciferase from Renilla (2008), Protein Sci., 17, 725-735.
    View publication on PubMedView publication on EuropePMC

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular docking simulations with the coelenterazine substrate. Two triads of residues are critical for catalysis. Putative catalytic triad residues D120, E144, and H285 bear only limited resemblance to those of aequorin. Residues N53, W121, and P220 are also involved in catalysis Renilla reniformis

Protein Variants

Protein Variants Comment Organism
A164W 73% of wild-type activity Renilla reniformis
D120E 1.1% of wild-type activity Renilla reniformis
D120F no activity detected Renilla reniformis
D120Y no activity detected Renilla reniformis
E144D 5.6% of wild-type activity Renilla reniformis
E144F no activity detected Renilla reniformis
E144Y no activity detected Renilla reniformis
E160N 27.2% of wild-type activity Renilla reniformis
F180C 14.3% of wild-type activity Renilla reniformis
F180T 5.4% of wild-type activity Renilla reniformis
F180Y 11.0% of wild-type activity Renilla reniformis
F180Y 61.8% of wild-type activity Renilla reniformis
F261A no activity detected Renilla reniformis
F261S no activity detected Renilla reniformis
H285A 11.3% of wild-type activity Renilla reniformis
H285D no activity detected Renilla reniformis
H285K no activity detected Renilla reniformis
H285N 0.1% of wild-type activity Renilla reniformis
I140L 113% of wild-type activity Renilla reniformis
I163F 11.0% of wild-type activity Renilla reniformis
I223W 0.2% of wild-type activity Renilla reniformis
K189D 24.7% of wild-type activity Renilla reniformis
K193S 54.8% of wild-type activity Renilla reniformis
K308I 47.5% of wild-type activity Renilla reniformis
M185G 16.7% of wild-type activity Renilla reniformis
N53C 3.4% of wild-type activity Renilla reniformis
N53G 0.5% of wild-type activity Renilla reniformis
N53H 2.1% of wild-type activity Renilla reniformis
N53M 1.8% of wild-type activity Renilla reniformis
N53P no activity detected Renilla reniformis
N53Q 25.1% of wild-type activity Renilla reniformis
N53R 90% of wild-type activity Renilla reniformis
N53S 20.7% of wild-type activity Renilla reniformis
P157R 101% of wild-type activity Renilla reniformis
P220C 72.7% of wild-type activity Renilla reniformis
P220E 4.9% of wild-type activity Renilla reniformis
P220F 15.7% of wild-type activity Renilla reniformis
P220G 548% of wild-type activity Renilla reniformis
P220L 500% of wild-type activity Renilla reniformis
P220M 140% of wild-type activity Renilla reniformis
P220Q 222% of wild-type activity Renilla reniformis
P220S 55.4% of wild-type activity Renilla reniformis
P220T 89.6% of wild-type activity Renilla reniformis
P220V 70.5% of wild-type activity Renilla reniformis
T184C 62.7% of wild-type activity Renilla reniformis
T184F 46.1% of wild-type activity Renilla reniformis
W121A 26.8% of wild-type activity Renilla reniformis
W121G 4.9% of wild-type activity Renilla reniformis
W121R 1.1% of wild-type activity Renilla reniformis
W121S 17.3% of wild-type activity Renilla reniformis
W121Y 3.1% of wild-type activity Renilla reniformis

Inhibitors

Inhibitors Comment Organism Structure
diethyldicarbonate
-
Renilla reniformis

Organism

Organism UniProt Comment Textmining
Renilla reniformis P27652
-
-