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Literature summary for 1.13.12.24 extracted from

  • Watkins, N.; Campbell, A.
    Requirement of the C-terminal proline residue for stability of the Ca2+-activated photoprotein aequorin (1993), Biochem. J., 293, 181-185 .
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information the C-terminal proline residue of aequorin is essential for the long-term stability of the bound coelenterazine. Aequorin lacking the proline residue has only 1% of the specific activity of the wild-type after 2 h, and is virtually inactive after 18 h. Replacement of the C-terminal proline residue with histidine or glutamic acid decreases the specific activity to 10 and 190% of that of the wild-type respectively, these variants show half-lives of 2.4 h and 2.3 h, respectively Aequorea victoria

Organism

Organism UniProt Comment Textmining
Aequorea victoria P02592
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