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Literature summary for 1.13.12.16 extracted from
- Rv1894c is a novel hypoxia-induced nitronate monooxygenase required for Mycobacterium tuberculosis virulence (2013), J. Infect. Dis., 207, 1525-1534.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed as a His-tagged fusion protein in Escherichia coli | Mycobacterium tuberculosis |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H199A | mutant shows no enzymatic function | Mycobacterium tuberculosis |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Superoxide dismutase | - |
Mycobacterium tuberculosis |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| using Ni-NTA chromatography | Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 2-nitropropane + O2 | - |
Mycobacterium tuberculosis | acetone + HNO2 | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| nitronate monooxygenase | - |
Mycobacterium tuberculosis |
| Rv1894c | - |
Mycobacterium tuberculosis |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Mycobacterium tuberculosis | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Mycobacterium tuberculosis | negatively regulated by the transcriptional repressor KstR | down |
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Release 2023.1 (January 2023)
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