Protein Variants | Comment | Organism |
---|---|---|
Y53F | the substitution of a conserved tyrosine residue at the active site of dihydroneopterin aldolase by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin rather than 6-hydroxymethyl-7,8-dihydropterin | Escherichia coli |
Y54F | the substitution of a conserved tyrosine residue at the active site of dihydroneopterin aldolase by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin rather than 6-hydroxymethyl-7,8-dihydropterin | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydroneopterin + O2 | Staphylococcus aureus | - |
7,8-dihydroxanthopterin + formate + glycolaldehyde | - |
? | |
7,8-dihydroneopterin + O2 | Escherichia coli | - |
7,8-dihydroxanthopterin + formate + glycolaldehyde | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0AC16 | - |
- |
Staphylococcus aureus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
7,8-dihydroneopterin + O2 | - |
Staphylococcus aureus | 7,8-dihydroxanthopterin + formate + glycolaldehyde | - |
? | |
7,8-dihydroneopterin + O2 | - |
Escherichia coli | 7,8-dihydroxanthopterin + formate + glycolaldehyde | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydroneopterin oxygenase | - |
Staphylococcus aureus |
dihydroneopterin oxygenase | - |
Escherichia coli |
Y53F mutant of dihydroneopterin aldolase | substitution of a conserved tyrosine residue at the active site of dihydroneopterin aldolase by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin rather than 6-hydroxymethyl-7,8-dihydropterin | Escherichia coli |
Y54F mutant of dihydroneopterin aldolase | substitution of a conserved tyrosine residue at the active site of dihydroneopterin aldolase by phenylalanine converts the enzyme to a cofactor-independent oxygenase, which generates mainly 7,8-dihydroxanthopterin rather than 6-hydroxymethyl-7,8-dihydropterin | Staphylococcus aureus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | cofactor-independent | Staphylococcus aureus | |
additional information | cofactor-independent | Escherichia coli |