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Literature summary for 1.13.11.63 extracted from

  • Smith, J.W.; Ford, N.A.; Thomas-Ahner, J.M.; Moran, N.E.; Bolton, E.C.; Wallig, M.A.; Clinton, S.K.; Erdman, J.W.
    Mice lacking beta-carotene-15,15'-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation (2016), Am. J. Physiol. Regul. Integr. Comp. Physiol., 311, R1135-R1148 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene bco1, quantitative PCR enzyme expression analysis Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
beta-carotene + O2 Mus musculus
-
 2 all-trans-retinal
-
 ?
beta-carotene + O2 Mus musculus C57BL/6J
-
 2 all-trans-retinal
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9JJS6
-
-
Mus musculus C57BL/6J Q9JJS6
-
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information Bco1 tissue expression analysis Mus musculus
-
prostate
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-carotene + O2
-
 Mus musculus 2 all-trans-retinal
-
 ?
beta-carotene + O2
-
 Mus musculus C57BL/6J 2 all-trans-retinal
-
 ?

Synonyms

Synonyms Comment Organism
BCO1
-
 Mus musculus
beta-carotene-15,15'-dioxygenase
-
 Mus musculus

General Information

General Information Comment Organism
malfunction mice lacking beta-carotene-15,15'-dioxygenase exhibit reduced serum testosterone, prostatic androgen receptor signaling, and prostatic cellular proliferation. Bco1 disruption also impacts diverse physiological end points independent of dietary carotenoid feeding, including expression of genes controlling androgen metabolism. co1 disruption significantly reduced Leydig cell number and decreased testicular mRNA expression of Hsd17b3, suggesting inhibition of testicular testosterone synthesis. Decreased androgen receptor nuclear localization in the dorsolateral prostate lobes of Bco1-/- mice. Analysis of prostatic morphology suggests a decreases in gland size and secretion, supported by reduced expression of the proliferation marker Ki-67 in Bco1-/- prostates. Genes differentially regulated in prostates of Bco1?/? mice, overview. Bco1 disruption alters prostatic morphology, reduces prostatic androgen receptor localization, and alters prostatic androgen signaling, but does not impact androgen receptor expression Mus musculus
physiological function beta-carotene-15,15'-dioxygenase (BCO1) cleaves dietary carotenoids at the central 15,15' double bond, most notably acting on beta-carotene to yield retinal Mus musculus