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Literature summary for 1.13.11.63 extracted from
- Importance of beta,beta-carotene 15,15-monooxygenase 1 (BCMO1) and beta,beta-carotene 9,10-dioxygenase 2 (BCDO2) in nutrition and health (2012), Mol. Nutr. Food Res., 56, 241-250.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | mutations in any of the four conserved histidine residues His172, His237, His308 and His514 or Glu405 result in the total loss of BCMO1 activity | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Homo sapiens | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Drosophila melanogaster |  |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Danio rerio | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Homo sapiens | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Gallus gallus | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Oryctolagus cuniculus | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Rattus norvegicus | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre | Cavia porcellus | |
| Fe2+ | the enzyme requires Fe2+ as an essential cofactor that binds to four conserved histidine residues in the active centre. Fe2+ is coordinated by the four histidines, water and molecular oxygen forming an octahedral arrangement with cation-pi stabilisation by Y235 and Y326 in the BCMO1 active site | Mus musculus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| beta-carotene + O2 | Drosophila melanogaster | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Danio rerio | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Mus musculus | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Homo sapiens | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Gallus gallus | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Oryctolagus cuniculus | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Rattus norvegicus | - |
2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | Cavia porcellus | - |
2 all-trans-retinal | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | H0VRY9 | - |
- |
| Danio rerio | - |
- |
- |
| Drosophila melanogaster | - |
- |
- |
| Gallus gallus | Q9I993 | - |
- |
| Homo sapiens | Q9HAY6 | - |
- |
| Mus musculus | Q9JJS6 | - |
- |
| Mustela putorius furo | - |
- |
- |
| no activity in Arabidopsis thaliana | - |
- |
- |
| no activity in Zea mays | - |
- |
- |
| Oryctolagus cuniculus | G1SEP0 | - |
- |
| Rattus norvegicus | Q91XT5 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| adipocyte | - |
Mus musculus | - |
| adrenal gland | - |
Homo sapiens | - |
| ciliary body | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| duodenum | - |
Mus musculus | - |
| eye | - |
Homo sapiens | - |
| gland | - |
Homo sapiens | - |
| hepatic stellate cell | - |
Mus musculus | - |
| hepatocyte | - |
Homo sapiens | - |
| intestinal mucosa | - |
Mus musculus | - |
| intestinal mucosa | - |
Mustela putorius furo | - |
| intestinal mucosa | - |
Homo sapiens | - |
| intestinal mucosa | - |
Oryctolagus cuniculus | - |
| intestinal mucosa | - |
Rattus norvegicus | - |
| intestinal mucosa | - |
Cavia porcellus | - |
| jejunum | - |
Mus musculus | - |
| keratinocyte | of skin squamous epithelium | Homo sapiens | - |
| kidney | - |
Homo sapiens | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| mammary gland | - |
Homo sapiens | - |
| ovary | - |
Homo sapiens | - |
| pancreas | cells comprising the exocrine gland | Homo sapiens | - |
| prostate | glandular cells | Homo sapiens | - |
| retinal pigment epithelium | - |
Homo sapiens | - |
| skeletal muscle | - |
Homo sapiens | - |
| small intestine | - |
Homo sapiens | - |
| stomach | mucosal and glandular cells | Homo sapiens | - |
| testis | - |
Homo sapiens | - |
| uterine endometrium | - |
Homo sapiens | - |
| white adipose tissue | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3',4'-dehydro-18'-oxo-gamma-carotene + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| 9,13-dicis-beta-carotene + O2 | - |
Rattus norvegicus | ? | - |
? | |
| 9-13-dicis-beta-carotene + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| alpha-carotene + O2 | - |
Gallus gallus | 2 all-trans-retinal | - |
? | |
| alpha-carotene + O2 | - |
Oryctolagus cuniculus | 2 all-trans-retinal | - |
? | |
| alpha-carotene + O2 | - |
Rattus norvegicus | 2 all-trans-retinal | - |
? | |
| beta-apo-10'-carotenal + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-apo-10'-carotenal + O2 | - |
Rattus norvegicus | ? | - |
? | |
| beta-apo-12'-carotenal + O2 | - |
Rattus norvegicus | ? | - |
? | |
| beta-apo-4'-carotenal + O2 | - |
Gallus gallus | ? | - |
? | |
| beta-apo-4'-carotenal + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-apo-8'-carotenal + O2 | - |
Gallus gallus | ? | - |
? | |
| beta-apo-8'-carotenal + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-apo-8'-carotenal + O2 | - |
Rattus norvegicus | ? | - |
? | |
| beta-carotene + O2 | - |
Drosophila melanogaster | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Danio rerio | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Mus musculus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Homo sapiens | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Gallus gallus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Oryctolagus cuniculus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Rattus norvegicus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | - |
Cavia porcellus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Drosophila melanogaster | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Danio rerio | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Mus musculus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Homo sapiens | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Gallus gallus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Oryctolagus cuniculus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Rattus norvegicus | 2 all-trans-retinal | - |
? | |
| beta-carotene + O2 | BCMO1 cleaves at the central 15,15' position of the polyene chain producing two molecules of retinal | Cavia porcellus | 2 all-trans-retinal | - |
? | |
| beta-cryptoxanthin + O2 | - |
Homo sapiens | ? | - |
? | |
| beta-cryptoxanthin + O2 | - |
Gallus gallus | ? | - |
? | |
| beta-cryptoxanthin + O2 | - |
Oryctolagus cuniculus | ? | - |
? | |
| beta-cryptoxanthin + O2 | - |
Rattus norvegicus | ? | - |
? | |
| gamma-carotene + O2 | - |
Gallus gallus | 2 all-trans-retinal | - |
? | |
| additional information | substrate specificity for BCMO1, overview | Drosophila melanogaster | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview | Danio rerio | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview | Mustela putorius furo | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin | Mus musculus | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin | Homo sapiens | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin. Specificity of BCMO1 towards substrates decreased in the order: beta-carotene, beta-cryptoxanthin, beta-apo-8'-carotenal, beta-apo-4'-carotenal, alpha-carotene, gamma-carotene | Rattus norvegicus | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin. Specificity of BCMO1 towards substrates decreases in the order: beta-carotene, beta-cryptoxanthin, beta-apo-8'-carotenal, beta-apo-4'-carotenal, alpha-carotene, gamma-carotene | Gallus gallus | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin. Specificity of BCMO1 towards substrates decreases in the order: beta-carotene, beta-cryptoxanthin, beta-apo-8'-carotenal, beta-apo-4'-carotenal, alpha-carotene, gamma-carotene | Oryctolagus cuniculus | ? | - |
? | |
| additional information | substrate specificity for BCMO1, overview. BCMO1 requires at least one unsubstituted beta-ionone ring for the cleavage of carotenoid substrates, but also the presence and position of methyl groups on the polyene chain are important. Therefore, activity is limited mainly to alpha- and beta-carotene, beta-apo-carotenals and beta-cryptoxanthin. Specificity of BCMO1 towards substrates decreases in the order: beta-carotene, beta-cryptoxanthin, beta-apo-8'-carotenal, beta-apo-4'-carotenal, alpha-carotene, gamma-carotene | Cavia porcellus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Bcmo1 | - |
Mus musculus |
| Bcmo1 | - |
Mustela putorius furo |
| Bcmo1 | - |
Homo sapiens |
| Bcmo1 | - |
Gallus gallus |
| Bcmo1 | - |
Oryctolagus cuniculus |
| Bcmo1 | - |
Rattus norvegicus |
| Bcmo1 | - |
Cavia porcellus |
| Bcox | - |
Danio rerio |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Drosophila melanogaster |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Danio rerio |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Mus musculus |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Mustela putorius furo |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Homo sapiens |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Gallus gallus |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Oryctolagus cuniculus |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Rattus norvegicus |
| beta,beta-carotene 15,15-monooxygenase 1 | - |
Cavia porcellus |
| NinaB | - |
Drosophila melanogaster |
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