Application | Comment | Organism |
---|---|---|
pharmacology | IDO-1 is a target for pharmacological inhibition in the treatment of cancer | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(10Z,13Z)-nonadecadienoic acid | 32% inhibition at 0.02 mM | Homo sapiens | |
(11Z,14Z)-eicosadienoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
(11Z,14Z,17Z)-eisosatrienoic acid | 19% inhibition at 0.02 mM | Homo sapiens | |
(12Z,15Z)-heneicosadienoic acid | 39% inhibition at 0.02 mM | Homo sapiens | |
(13Z,16Z)-docosadienoic acid | 39% inhibition at 0.02 mM | Homo sapiens | |
(13Z,16Z,19Z)-docosatrienoic acid | 52% inhibition at 0.02 mM | Homo sapiens | |
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoic acid | 48% inhibition at 0.02 mM | Homo sapiens | |
(4Z,7Z,10Z,13Z,16Z,19Z)-Docosahexaenoic acid | 35% inhibition at 0.02 mM | Homo sapiens | |
(5Z,8Z)-7,7-dimethyl-5,8-eicosadienoic acid | 29% inhibition at 0.02 mM | Homo sapiens | |
(5Z,8Z)-eicosadienoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
(5Z,8Z,11Z)-eisosatrienoic acid | 45% inhibition at 0.02 mM | Homo sapiens | |
(5Z,8Z,11Z,14Z)-eicosatetraenoic acid | 55% inhibition at 0.02 mM; 80% inhibition at 0.02 mM | Homo sapiens | |
(5Z,8Z,11Z,14Z,17Z)-eicosapentaenoic acid | 19% inhibition at 0.02 mM | Homo sapiens | |
(7Z,10Z,13Z,16Z)-docosatetraenoic acid | 42% inhibition at 0.02 mM | Homo sapiens | |
(8Z,11Z,14Z)-eisosatrienoic acid | 68% inhibition at 0.02 mM | Homo sapiens | |
(9E,11Z)-octadecadienoic acid | 26% inhibition at 0.02 mM | Homo sapiens | |
(9E,12E)-octadecadienoic acid | 23% inhibition at 0.02 mM | Homo sapiens | |
(9Z,12Z)-octadecadienoic acid | 16% inhibition at 0.02 mM | Homo sapiens | |
(9Z,12Z,15Z)-octadecatrienoic acid | 23% inhibition at 0.02 mM | Homo sapiens | |
15-deoxy-DELTA12,14-prostaglandin | - |
Homo sapiens | |
arachidonate | - |
Homo sapiens | |
additional information | inhibition of indoleamine 2,3-dioxygenase activity by fatty acids, eicosanoids and prostaglandins, structure-function-analysis, overview. No inhibition by (6Z,9Z,12Z)-octadecatrienoic and (6Z,9Z,12Z,15Z)-octadecatetraenoic | Homo sapiens | |
prostaglandin (19R)-hydroxy-PGE2 | - |
Homo sapiens | |
prostaglandin 13,14-dihydro-15-oxo-PGE2 | - |
Homo sapiens | |
prostaglandin 15-oxo-PGE2 | - |
Homo sapiens | |
prostaglandin 15-oxo-PGF2alpha | - |
Homo sapiens | |
prostaglandin 20-hydroxy PGE2 | - |
Homo sapiens | |
prostaglandin DELTA12-PGJ2 | - |
Homo sapiens | |
prostaglandin PGA2 | - |
Homo sapiens | |
prostaglandin PGD2 | - |
Homo sapiens | |
prostaglandin PGD2 ethanolamide | - |
Homo sapiens | |
prostaglandin PGE2 | - |
Homo sapiens | |
prostaglandin PGE2 ethanolamide | - |
Homo sapiens | |
prostaglandin PGF2beta | - |
Homo sapiens | |
prostaglandin PGG2 | - |
Homo sapiens | |
prostaglandin PGH2 | - |
Homo sapiens | |
prostaglandin PGJ2 | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
IDO-1 | - |
Homo sapiens |
indoleamine 2,3-dioxygenase-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0041 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGD2 | |
0.0042 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGJ2 | |
0.0044 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin | |
0.0046 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin DELTA12-PGJ2 | |
0.0046 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGE2 ethanolamide | |
0.0047 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGD2 ethanolamide | |
0.0049 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGA2 | |
0.0057 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGD2 ethanolamide | |
0.006 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin (19R)-hydroxy-PGE2 | |
0.0063 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGE2 ethanolamide | |
0.0067 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 13,14-dihydro-15-oxo-PGE2 | |
0.0067 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGJ2 | |
0.0068 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 15-oxo-PGE2 | |
0.0071 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGF2beta | |
0.0071 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin DELTA12-PGJ2 | |
0.0072 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGH2 | |
0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGD2 | |
0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGF2beta | |
0.0074 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 20-hydroxy PGE2 | |
0.0076 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 15-oxo-PGF2alpha | |
0.0078 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGA2 | |
0.009 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 15-oxo-PGE2 | |
0.0092 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGG2 | |
0.0095 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin (19R)-hydroxy-PGE2 | |
0.0096 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGH2 | |
0.01 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin PGE2 | |
0.0112 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGG2 | |
0.0112 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 20-hydroxy PGE2 | |
0.013 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin | |
0.0221 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin PGE2 | |
0.0231 | - |
pH not specified in the publication, 37°C, inhibition of human monocytes | Homo sapiens | prostaglandin 15-oxo-PGF2alpha | |
0.03 | - |
pH not specified in the publication, 37°C, inhibition of human THP-1 cells | Homo sapiens | prostaglandin 13,14-dihydro-15-oxo-PGE2 |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | arachinoate and the prostaglandin metabolite, PGD2, repress the IFNgamma mediated activity of IDO-1 in THP-1 cells and human monocytes | down |
General Information | Comment | Organism |
---|---|---|
physiological function | the enzyme catalyses the first and rate-limiting step in the metabolism of L-tryptophan. Degradation of L-Trp leads to the production of several immunosuppressive metabolites, including N-formyl kynurenine and kynurenine. Enzyme IDO-1 also plays a crucial role in immune suppression and tumour induced tolerance. IDO-1 acts as an inducible negative regulator of T cell viability, proliferation and activation | Homo sapiens |