Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-D-tryptophan | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
arteriole | - |
Mus musculus | - |
artery | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
IDO1 | - |
Mus musculus |
indoleamine 2,3-dioxygenase-1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | immune regulatory effects of Ido1 and ability of nitric oxide to regulate Ido1 activity, Ido1-mediated metabolism of tryptophan to kynurenine can modulate vascular tone After transient cerebral ischaemia induction in wild-type and Ido1 gene-deficient (Ido1-/-) mice, cerebral ischaemia-reperfusion in wild-type mice increases Ido activity and its expression in cerebral arterioles, while Ido1-/- and 1-methyl-D-tryptophan-treated wild-type mice have lower Ido activity but similar post-stroke neurological function and similar total brain infarct volume and swelling, relative to control mice. Ido1 expression does not appear to affect overall outcome following acute ischaemic stroke | Mus musculus |