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Literature summary for 1.13.11.52 extracted from

  • Jackman, K.A.; Brait, V.H.; Wang, Y.; Maghzal, G.J.; Ball, H.J.; McKenzie, G.; De Silva, T.M.; Stocker, R.; Sobey, C.G.
    Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice (2011), Naunyn Schmiedebergs Arch. Pharmacol., 383, 471-481.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-D-tryptophan
-
Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
arteriole
-
Mus musculus
-
artery
-
Mus musculus
-
brain
-
Mus musculus
-

Synonyms

Synonyms Comment Organism
IDO1
-
Mus musculus
indoleamine 2,3-dioxygenase-1
-
Mus musculus

General Information

General Information Comment Organism
physiological function immune regulatory effects of Ido1 and ability of nitric oxide to regulate Ido1 activity, Ido1-mediated metabolism of tryptophan to kynurenine can modulate vascular tone After transient cerebral ischaemia induction in wild-type and Ido1 gene-deficient (Ido1-/-) mice, cerebral ischaemia-reperfusion in wild-type mice increases Ido activity and its expression in cerebral arterioles, while Ido1-/- and 1-methyl-D-tryptophan-treated wild-type mice have lower Ido activity but similar post-stroke neurological function and similar total brain infarct volume and swelling, relative to control mice. Ido1 expression does not appear to affect overall outcome following acute ischaemic stroke Mus musculus