Literature summary for 1.13.11.52 extracted from

Bonda, D.J.; Mailankot, M.; Stone, J.G.; Garrett, M.R.; Staniszewska, M.; Castellani, R.J.; Siedlak, S.L.; Zhu, X.; Lee, H.G.; Perry, G.; Nagaraj, R.H.; Smith, M.A.
Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer�s disease (2010), Redox Rep., 15, 161-168.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-tryptophan + O2	Homo sapiens	-	N-formyl-L-kynurenine	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	IDO-1 is associated with senile plaques in Alzheimer's disease brains and is specifically localized in conjunction with neurofibrillary tangles	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
IDO-1	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	IDO-1 levels are increased in Alzheimer's disease brains compared to controls	up

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Release 2023.1 (January 2023)