Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21 AI cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(3-hydroxyphenyl)(phenyl)methanone | - |
Homo sapiens | |
(4E,4'E)-4,4'-bis(isopropylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione | - |
Homo sapiens | |
(4E,4'E)-4,4'-bis(pentan-3-ylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione | - |
Homo sapiens | |
(E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-one | - |
Homo sapiens | |
(R)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide | - |
Homo sapiens | |
(S)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide | - |
Homo sapiens | |
1-(1,3-benzothiazol-2-ylsulfanyl)-N,N-dimethylmethanamine | - |
Homo sapiens | |
1-methyl-L-tryptophan | - |
Homo sapiens | |
2-amino-3-hydroxy-N-(4-hydroxynaphthalen-1-yl)propanamide | - |
Homo sapiens | |
2-amino-N-(4-hydroxynaphth-1-yl)acetamide | - |
Homo sapiens | |
2-mercaptobenzothiazole | - |
Homo sapiens | |
2-phenoxyaniline | - |
Homo sapiens | |
3-(1H-1,2,3-triazol-5-yl)pyridine | - |
Homo sapiens | |
4-(1H-1,2,3-triazol-5-yl)pyridine | - |
Homo sapiens | |
4-(2-(diethylamino)ethylamino)-1-naphthol | - |
Homo sapiens | |
4-(2-hydroxyethoxy)-1-naphthol | - |
Homo sapiens | |
4-(benzylamino)-1-naphthol | - |
Homo sapiens | |
4-(cyclohexylamino)-1-naphthol | - |
Homo sapiens | |
4-(dimethylamino)naphthalen-1-ol | - |
Homo sapiens | |
4-(ethylamino)-1-naphthol | - |
Homo sapiens | |
4-(isobutylamino)-1-naphthol | - |
Homo sapiens | |
4-(isopropylamino)-1-naphthol | - |
Homo sapiens | |
4-(methylamino)naphthalen-1-ol | - |
Homo sapiens | |
4-(pent-3-ylamino)-1-naphthol | - |
Homo sapiens | |
4-(propylamino)-1-naphthol | - |
Homo sapiens | |
4-(tert-butylamino)naphthalen-1-ol | - |
Homo sapiens | |
4-amino-1-naphthol | - |
Homo sapiens | |
4-hydroxycarbazole | - |
Homo sapiens | |
4-methoxy-1-naphthylamine | - |
Homo sapiens | |
4-phenyl-1,3-thiazol-2-amine | - |
Homo sapiens | |
4-phenyl-1,3-thiazole-2-thiol | - |
Homo sapiens | |
5-(ethylamino)quinolin-8-ol | - |
Homo sapiens | |
5-(isopropylamino)quinolin-8-ol | - |
Homo sapiens | |
5-amino-8-hydroxyquinoline | - |
Homo sapiens | |
5-chloro-1,3-benzothiazole-2(3H)-thione | - |
Homo sapiens | |
5-phenyl-1H-1,2,3-triazole | - |
Homo sapiens | |
9-fluorenone | - |
Homo sapiens | |
9-hydroxyfluorene | - |
Homo sapiens | |
annulin B | - |
Homo sapiens | |
benzophenone | - |
Homo sapiens | |
brassinin | - |
Homo sapiens | |
Dichlorophene | - |
Homo sapiens | |
exiguamine A | - |
Homo sapiens | |
additional information | not inhibited by 1-methyl-D-tryptophan | Homo sapiens | |
N,N-dimethyl-1-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]methanamine | - |
Homo sapiens | |
N-(4-hydroxy-1-naphthyl)ethane-1,2-diaminium chloride | - |
Homo sapiens | |
N-(4-hydroxy-1-naphthyl)propane-1,3-diaminium chloride | - |
Homo sapiens | |
N-(4-hydroxynaphthalen-1-yl)pyrrolidine-2-carboxamide | - |
Homo sapiens | |
N-phenyl-p-phenylenediamine | - |
Homo sapiens | |
naphthalene-1,4-diol | - |
Homo sapiens | |
primaquine | - |
Homo sapiens | |
quinolin-8-ol | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Homo sapiens | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
serotonin + O2 | Homo sapiens | - |
? | - |
? | |
tryptamine + O2 | Homo sapiens | - |
? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Purification (Comment) | Organism |
---|---|
IMAC nickel affinity column chromatography | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
serotonin + O2 | - |
Homo sapiens | ? | - |
? | |
tryptamine + O2 | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0002 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (E)-4-(isopropylimino)-2-methylnaphthalen-1(4H)-one | |
0.00045 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (4E,4'E)-4,4'-bis(isopropylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione | |
0.00052 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (4E,4'E)-4,4'-bis(pentan-3-ylimino)-2,2'-binaphthyl-1,1'-(4H,4'H)-dione | |
0.0015 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | naphthalene-1,4-diol | |
0.0025 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(isopropylamino)-1-naphthol | |
0.0025 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(benzylamino)-1-naphthol | |
0.003 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-amino-1-naphthol | |
0.003 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 5-amino-8-hydroxyquinoline | |
0.003 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(2-(diethylamino)ethylamino)-1-naphthol | |
0.0035 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(pent-3-ylamino)-1-naphthol | |
0.004 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(tert-butylamino)naphthalen-1-ol | |
0.0045 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(propylamino)-1-naphthol | |
0.005 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(1H-1,2,3-triazol-5-yl)pyridine | |
0.005 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | N-(4-hydroxy-1-naphthyl)propane-1,3-diaminium chloride | |
0.0055 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-methoxy-1-naphthylamine | |
0.0125 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(methylamino)naphthalen-1-ol | |
0.0125 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(2-hydroxyethoxy)-1-naphthol | |
0.015 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 5-(isopropylamino)quinolin-8-ol | |
0.015 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(cyclohexylamino)-1-naphthol | |
0.016 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(ethylamino)-1-naphthol | |
0.025 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(isobutylamino)-1-naphthol | |
0.04 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 5-(ethylamino)quinolin-8-ol | |
0.044 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | N-(4-hydroxy-1-naphthyl)ethane-1,2-diaminium chloride | |
0.05 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | primaquine | |
0.05 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 2-mercaptobenzothiazole | |
0.05 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 5-chloro-1,3-benzothiazole-2(3H)-thione | |
0.05 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 1-(1,3-benzothiazol-2-ylsulfanyl)-N,N-dimethylmethanamine | |
0.05 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-phenyl-1,3-thiazole-2-thiol | |
0.06 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 5-phenyl-1H-1,2,3-triazole | |
0.06 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (S)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide | |
0.07 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | Dichlorophene | |
0.09 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (R)-2-amino-N-(4-hydroxynaphth-1-yl)propanamide | |
0.105 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 2-amino-N-(4-hydroxynaphth-1-yl)acetamide | |
0.2 | - |
IC50 above 0.2 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 9-fluorenone | |
0.2 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | N-(4-hydroxynaphthalen-1-yl)pyrrolidine-2-carboxamide | |
0.4 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | N-phenyl-p-phenylenediamine | |
0.4 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 2-amino-3-hydroxy-N-(4-hydroxynaphthalen-1-yl)propanamide | |
0.4 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-hydroxycarbazole | |
0.5 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | (3-hydroxyphenyl)(phenyl)methanone | |
0.68 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 3-(1H-1,2,3-triazol-5-yl)pyridine | |
0.75 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | quinolin-8-ol | |
1 | - |
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 9-hydroxyfluorene | |
1 | - |
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | N,N-dimethyl-1-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]methanamine | |
1 | - |
IC50 above 1.0 mM, in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 2-phenoxyaniline | |
1 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | benzophenone | |
1 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-phenyl-1,3-thiazol-2-amine | |
1 | - |
in potassium phosphate buffer (100 mM, pH 6.5) ascorbic acid (20 mM), catalase (200 units/ml), methylene blue (0.01 mM), at 37°C | Homo sapiens | 4-(dimethylamino)naphthalen-1-ol |
General Information | Comment | Organism |
---|---|---|
metabolism | IDO catalyzes the initial and rate-limiting step in the catabolism of tryptophan along the kynurenine pathway | Homo sapiens |