Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.13.11.52 extracted from

  • Jiang, G.M.; He, Y.W.; Fang, R.; Zhang, G.; Zeng, J.; Yi, Y.M.; Zhang, S.; Bu, X.Z.; Cai, S.H.; Du, J.
    Sodium butyrate down-regulation of indoleamine 2, 3-dioxygenase at the transcriptional and post-transcriptional levels (2010), Int. J. Biochem. Cell Biol., 42, 1840-1846.
    View publication on PubMed
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
additional information sodium butyrate does not inhibit the activity of IDO Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
43000
-
 SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CNE-2 cell
-
 Homo sapiens
-
nasopharyngeal carcinoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-L-tryptophan + O2
-
 Homo sapiens N-formyl-5-hydroxy-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens
indoleamine 2, 3-dioxygenase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens sodium butyrate down-regulates indoleamine 2,3-dioxygenase at the transcriptional and post-transcriptional levels. Treatment with sodium butyrate (up to 0.2 mM) significantly reduces IDO induction, which is almost completely inhibited at a concentration of 0.5 mM. Sodium butyrate causes a ubiquitin-mediated proteasomal degradation process that contributes to degradation of IDO. Treatment with bortezomib significantly represses sodium butyrate-induced down-regulation of IDO protein down
Homo sapiens IDO expression is induced by interferon-gamma. IDO is detected when exposed to 100 units/ml IFN-gamma for 4 h and is enhanced by continuous exposure to IFN-gamma up