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Literature summary for 1.13.11.52 extracted from
- Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells: apoptosis through the formation of 3-hydroxykynurenine (2010), Int. J. Biochem. Cell Biol., 42, 1446-1454.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-methyl-DL-tryptophan | - |
Homo sapiens |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 42000 | - |
SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | Homo sapiens | - |
N-formyl-L-kynurenine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HLE-B3 cell | - |
Homo sapiens | - |
| lens epithelium | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IDO | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | - |
Homo sapiens | |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | interferon-gamma induces the expression of indoleamine 2,3-dioxygenase, an 100fold and 200fold increase in IDO activity is detected with IFN-gamma concentrations of 5 and 10 units/ml, respectively | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | the induction of IDO by interferon-gamma in HLE-B3 cells causes increases in intracellular reactive oxygen species, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content, are accompanied by apoptosis. IDO-mediated kynurenine formation plays a role in cataract formation related to chronic inflammation | Homo sapiens |
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