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Literature summary for 1.13.11.52 extracted from

  • Juergens, B.; Fuchs, D.; Reichenbach, J.; Heitger, A.
    Intact indoleamine 2,3-dioxygenase activity in human chronic granulomatous disease (2010), Clin. Immunol., 137, 1-4.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
additional information reactive oxygen intermediates are dispensable for indoleamine 2,3-dioxygenase activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
dendritic cell mature, but not immature dendritic cells metabolize tryptophan Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?

Synonyms

Synonyms Comment Organism
IDO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function indoleamine 2,3-dioxygenase is critical for regulating immune responses and suppression of inflammation. In human chronic granulomatous disease, IDO metabolic activity is intact Homo sapiens