Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-D-tryptophan | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Mus musculus | - |
N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone marrow-derived dendritic cell | - |
Mus musculus | - |
dendritic cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
IDO | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | IDO expression is abrogated by the heme oxygenase inhibitor zinc protoporphrin (5 mg/kg, i.p.). Heme oxygenase-1 downregulation decreases lipopolysaccharide-induced IDO expression in murine dendritic cells. Lipopolysaccharide induces high IDO expression | down |
Mus musculus | IDO expression in bone marrow-derived dendritic cells is increased by hemin, a potent inducer of heme oxygenase-1 | up |
General Information | Comment | Organism |
---|---|---|
malfunction | IDO deficiency leads to diminished phenotypic and functional maturation of dendritic cells in vitro and in vivo | Mus musculus |
metabolism | IDO is a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation | Mus musculus |