Literature summary for 1.13.11.52 extracted from

Arefayene, M.; Philips, S.; Cao, D.; Mamidipalli, S.; Desta, Z.; Flockhart, D.A.; Wilkes, D.S.; Skaar, T.C.
Identification of genetic variants in the human indoleamine 2,3-dioxygenase (IDO1) gene, which have altered enzyme activity (2009), Pharmacogenet. Genomics, 19, 464-476.

Search for more literature for 1.13.11.52

Application

Application	Comment	Organism
medicine	identification of genetic variants, which have altered enzyme activity	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
expressed in COS-7 and HEK293 cell, C-terminal hemagglutinin-tagged	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
A4T	variant observed in Homo sapiens	Homo sapiens
additional information	in a 9 bp-deletion variant (observed in Homo sapiens) 4 amino acid residues (199-202: ALLE) are replaced by D	Homo sapiens
additional information	variant L197I observed in Homo sapiens	Homo sapiens
R77H	variant observed in Homo sapiens	Homo sapiens
R77K	variant not observed in Homo sapiens, used as control	Homo sapiens

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.018	-	L-tryptophan	-	Homo sapiens
0.0234	-	L-tryptophan	A4T mutant protein	Homo sapiens
0.0296	-	L-tryptophan	R77H mutant protein	Homo sapiens
0.0342	-	L-tryptophan	R77K mutant protein	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P14902	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-tryptophan + O2	-	Homo sapiens	N-formyl-L-kynurenine	-	?

Synonyms

Synonyms	Comment	Organism
indoleamine 2,3-dioxygenase	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
heme	-	Homo sapiens

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Release 2023.1 (January 2023)