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Literature summary for 1.13.11.52 extracted from

  • Macchiarulo, A.; Camaioni, E.; Nuti, R.; Pellicciari, R.
    Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease (2009), Amino Acids, 37, 219-229.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-L-tryptophan
-
Homo sapiens
1-methyl-L-tryptophan
-
Mus musculus
additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens
additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus
vitamin K3 menadione Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-
Mus musculus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
L-tryptophan + O2 = N-formyl-L-kynurenine Criegee type rearrangement for ring opening Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
Mus musculus N-formylkynurenine
-
?
L-tryptophan + O2
-
Homo sapiens N-formylkynurenine
-
?

Subunits

Subunits Comment Organism
monomer
-
Mus musculus
monomer
-
Homo sapiens

Synonyms

Synonyms Comment Organism
indoleamine 2,3-dioxygenase
-
Mus musculus
indoleamine 2,3-dioxygenase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus
heme
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus
additional information
-
additional information review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens
0.062
-
1-methyl-L-tryptophan
-
Homo sapiens
0.105
-
1-methyl-L-tryptophan
-
Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Mus musculus additional information
additional information
-
review article sumarizing data of many inhibitors of indoleamine 2,3-dioxygenase Homo sapiens additional information
0.001
-
-
Homo sapiens vitamin K3