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Literature summary for 1.13.11.52 extracted from

  • King, N.J.; Thomas, S.R.
    Molecules in focus: indoleamine 2,3-dioxygenase (2007), Int. J. Biochem. Cell Biol., 39, 2167-2172.
    View publication on PubMed
Search for more literature for 1.13.11.52

Application

Application Comment Organism
medicine target for therapeutic intervention. Inhibition of inappropriate IDO activity in tumours in vivo may attenuate the ability of tumours to evade immune surveillance and promote clearance. Strategies that enhance IDO activity during autoimmune or inflammatory diseases may be beneficial via inhibition of undesirable T cell activities Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45000
-
 x * 45000, calculated from sequence Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Homo sapiens
-
 N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 Mus musculus IDO represents an important immune regulatory enzyme under diverse physiological and pathological conditions in vivo and is of considerable medical importance N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2
-
 Homo sapiens N-formyl-L-kynurenine
-
 ?
L-tryptophan + O2 IDO represents an important immune regulatory enzyme under diverse physiological and pathological conditions in vivo and is of considerable medical importance Mus musculus N-formyl-L-kynurenine
-
 ?

Subunits

Subunits Comment Organism
? x * 45000, calculated from sequence Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
 Mus musculus
heme
-
 Homo sapiens