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Literature summary for 1.13.11.52 extracted from

  • Austin, C.J.; Astelbauer, F.; Kosim-Satyaputra, P.; Ball, H.J.; Willows, R.D.; Jamie, J.F.; Hunt, N.H.
    Mouse and human indoleamine 2,3-dioxygenase display some distinct biochemical and structural properties (2009), Amino Acids, 36, 99-106.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
large scale expression in Escherichia coli Mus musculus
large scale expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-L-tryptophan
-
Homo sapiens
1-methyl-L-tryptophan
-
Mus musculus
norharman
-
Homo sapiens
norharman
-
Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.026
-
L-tryptophan 37°C, pH 6.5 Mus musculus
0.074
-
L-tryptophan 37°C, pH 6.5 Homo sapiens
0.21
-
5-hydroxy-L-tryptophan 37°C, pH 6.5 Mus musculus
0.68
-
5-hydroxy-L-tryptophan 37°C, pH 6.5 Homo sapiens
5.2
-
D-tryptophan 37°C, pH 6.5 Homo sapiens
7.3
-
D-tryptophan 37°C, pH 6.5 Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P14902
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Mus musculus
-
Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.6
-
-
Mus musculus
4.7
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-hydroxy-L-tryptophan + O2
-
Mus musculus (2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
-
?
5-hydroxy-L-tryptophan + O2
-
Homo sapiens (2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid
-
?
D-tryptophan + O2
-
Mus musculus N-formyl-D-kynurenine
-
?
D-tryptophan + O2
-
Homo sapiens N-formyl-D-kynurenine
-
?
L-tryptophan + O2
-
Mus musculus N-formyl-L-kynurenine
-
?
L-tryptophan + O2
-
Homo sapiens N-formyl-L-kynurenine
-
?

Subunits

Subunits Comment Organism
? x * 45000-50000, SDS-PAGE Mus musculus
? x * 45000-50000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
hIDO
-
Homo sapiens
mIDO
-
Mus musculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
-
Mus musculus
6.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
5 7 pH 5.0: about 50% of maximal activity, pH 7.0: about 65% of maximal activity Mus musculus
5 7.5 pH 5.0: about 50% of maximal activity, pH 7.5: about 65% of maximal activity Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme
-
Mus musculus
heme
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.062
-
1-methyl-L-tryptophan 37°C, pH 6.5 Homo sapiens
0.105
-
1-methyl-L-tryptophan 37°C, pH 6.5 Mus musculus
1.08
-
norharman 37°C, pH 6.5 Mus musculus
1.28
-
norharman 37°C, pH 6.5 Homo sapiens