Cloned (Comment) | Organism |
---|---|
large scale expression in Escherichia coli | Mus musculus |
large scale expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-methyl-L-tryptophan | - |
Homo sapiens | |
1-methyl-L-tryptophan | - |
Mus musculus | |
norharman | - |
Homo sapiens | |
norharman | - |
Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
L-tryptophan | 37°C, pH 6.5 | Mus musculus | |
0.074 | - |
L-tryptophan | 37°C, pH 6.5 | Homo sapiens | |
0.21 | - |
5-hydroxy-L-tryptophan | 37°C, pH 6.5 | Mus musculus | |
0.68 | - |
5-hydroxy-L-tryptophan | 37°C, pH 6.5 | Homo sapiens | |
5.2 | - |
D-tryptophan | 37°C, pH 6.5 | Homo sapiens | |
7.3 | - |
D-tryptophan | 37°C, pH 6.5 | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P14902 | - |
- |
Mus musculus | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
3.6 | - |
- |
Mus musculus |
4.7 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-hydroxy-L-tryptophan + O2 | - |
Mus musculus | (2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid | - |
? | |
5-hydroxy-L-tryptophan + O2 | - |
Homo sapiens | (2S)-4-(2-amino-5-hydroxyphenyl)-2-(formylamino)-4-oxobutanoic acid | - |
? | |
D-tryptophan + O2 | - |
Mus musculus | N-formyl-D-kynurenine | - |
? | |
D-tryptophan + O2 | - |
Homo sapiens | N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Mus musculus | N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | - |
Homo sapiens | N-formyl-L-kynurenine | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 45000-50000, SDS-PAGE | Mus musculus |
? | x * 45000-50000, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
hIDO | - |
Homo sapiens |
mIDO | - |
Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | - |
- |
Mus musculus |
6.5 | - |
- |
Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 7 | pH 5.0: about 50% of maximal activity, pH 7.0: about 65% of maximal activity | Mus musculus |
5 | 7.5 | pH 5.0: about 50% of maximal activity, pH 7.5: about 65% of maximal activity | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | - |
Mus musculus | |
heme | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.062 | - |
1-methyl-L-tryptophan | 37°C, pH 6.5 | Homo sapiens | |
0.105 | - |
1-methyl-L-tryptophan | 37°C, pH 6.5 | Mus musculus | |
1.08 | - |
norharman | 37°C, pH 6.5 | Mus musculus | |
1.28 | - |
norharman | 37°C, pH 6.5 | Homo sapiens |