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Literature summary for 1.13.11.52 extracted from

  • Bouknight, R.R.; Sadoff, H.L.
    Tryptophan catabolism in Bacillus megaterium (1975), J. Bacteriol., 121, 70-76.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information kynurenine induces both tryptophan oxygenase and kynureninase of the catabolic pathway of L-tryptophan degradation Priestia megaterium

Inhibitors

Inhibitors Comment Organism Structure
hydroxylamine
-
Priestia megaterium
additional information catabolite repression of the pathway by glucose and glutamate, arginine does not cause repression, no inhibition by D-tryptophan Priestia megaterium
potassium cyanide
-
Priestia megaterium
Sodium azide
-
Priestia megaterium

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+ the enzyme has a functional heme group Priestia megaterium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-tryptophan + O2 Priestia megaterium the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Priestia megaterium
-
strain ATCC 19213
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:L-tryptophan-grown cell cells grown in a medium containing L-tryptophan as the sole carbon, nitrogen, and energy source Priestia megaterium
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
poor activity in cells grown on arginine and on glucose, also in presence of L-tryptophan Priestia megaterium
12.5
-
cells grown on L-alanine Priestia megaterium
15.6
-
cells grown on L-asparagine Priestia megaterium
22.7
-
cells grown on L-tryptophan Priestia megaterium
23.5
-
cells grown on L-arginine Priestia megaterium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-tryptophan + O2 the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview Priestia megaterium N-formyl-L-kynurenine
-
?
L-tryptophan + O2 D-tryptophan is no substrate Priestia megaterium N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
tryptophan oxygenase
-
Priestia megaterium

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Priestia megaterium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
assay at Priestia megaterium