Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | kynurenine induces both tryptophan oxygenase and kynureninase of the catabolic pathway of L-tryptophan degradation | Priestia megaterium |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
hydroxylamine | - |
Priestia megaterium | |
additional information | catabolite repression of the pathway by glucose and glutamate, arginine does not cause repression, no inhibition by D-tryptophan | Priestia megaterium | |
potassium cyanide | - |
Priestia megaterium | |
Sodium azide | - |
Priestia megaterium |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | the enzyme has a functional heme group | Priestia megaterium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | Priestia megaterium | the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview | N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Priestia megaterium | - |
strain ATCC 19213 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
culture condition:L-tryptophan-grown cell | cells grown in a medium containing L-tryptophan as the sole carbon, nitrogen, and energy source | Priestia megaterium | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
poor activity in cells grown on arginine and on glucose, also in presence of L-tryptophan | Priestia megaterium |
12.5 | - |
cells grown on L-alanine | Priestia megaterium |
15.6 | - |
cells grown on L-asparagine | Priestia megaterium |
22.7 | - |
cells grown on L-tryptophan | Priestia megaterium |
23.5 | - |
cells grown on L-arginine | Priestia megaterium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-tryptophan + O2 | the enzyme is involved in the catabolic pathway of L-tryptophan degradation, overview | Priestia megaterium | N-formyl-L-kynurenine | - |
? | |
L-tryptophan + O2 | D-tryptophan is no substrate | Priestia megaterium | N-formyl-L-kynurenine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
tryptophan oxygenase | - |
Priestia megaterium |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Priestia megaterium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Priestia megaterium |