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BRENDA support

Literature summary for 1.13.11.52 extracted from

  • Fallarino, F.; Vacca, C.; Orabona, C.; Belladonna, M.L.; Bianchi, R.; Marshall, B.; Keskin, D.B.; Mellor, A.L.; Fioretti, M.C.; Grohmann, U.; Puccetti, P.
    Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells (2002), Int. Immunol., 14, 65-68.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
gamma-interferon
-
Mus musculus
O2-
-
Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-DL-tryptophan competitive inhibitor Mus musculus
NO
-
Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
dendrite
-
Mus musculus 30425
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + O2 Mus musculus
-
N-formyl-D-kynurenine
-
?
D-tryptophan + O2 Mus musculus DBA/2J
-
N-formyl-D-kynurenine
-
?
L-tryptophan + O2 Mus musculus
-
N-formyl-L-kynurenine
-
?
L-tryptophan + O2 Mus musculus DBA/2J
-
N-formyl-L-kynurenine
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
DBA/2J
-
Mus musculus DBA/2J
-
DBA/2J
-

Source Tissue

Source Tissue Comment Organism Textmining
peritoneal macrophage
-
Mus musculus
-
spleen dentritic cells Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
Mus musculus N-formyl-D-kynurenine
-
?
D-tryptophan + O2
-
Mus musculus DBA/2J N-formyl-D-kynurenine
-
?
L-tryptophan + O2
-
Mus musculus N-formyl-L-kynurenine
-
?
L-tryptophan + O2
-
Mus musculus DBA/2J N-formyl-L-kynurenine
-
?

Synonyms

Synonyms Comment Organism
IDO
-
Mus musculus