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Literature summary for 1.13.11.52 extracted from

  • Ozaki, Y.; Reinhard, J.F., Jr.; Nichol, C.A.
    Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase (1986), Biochem. Biophys. Res. Commun., 137, 1106-1111.
    View publication on PubMed
Search for more literature for 1.13.11.52

Inhibitors

Inhibitors Comment Organism Structure
L-tryptophan substrate inhibition at concentrations above 0.04 mM Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.01
-
 L-tryptophan pH 7.5, 37 °C, 5 min incubation time Mus musculus
0.062
-
 D-tryptophan pH 7.5, 37 °C, 40 min incubation time Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-tryptophan + O2 Mus musculus
-
 N-formyl-D-kynurenine
-
 ?
L-tryptophan + O2 Mus musculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
homogenization, ammonium sulfate precipitation, gel filtration with Sephacryl S200, Bio-gel HT column, stored at -75°C Mus musculus

Source Tissue

Source Tissue Comment Organism Textmining
epididymis
-
 Mus musculus
-

Storage Stability

Storage Stability Organism
-75°C Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-tryptophan + O2
-
 Mus musculus N-formyl-D-kynurenine
-
 ?
L-tryptophan + O2
-
 Mus musculus N-formyl-L-kynurenine
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
FMNH2 4-5-fold higher activity than acitivity with methylene blue as the electron donor Mus musculus
tetrahydrobiopterin
-
 Mus musculus