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Literature summary for 1.13.11.52 extracted from

  • Ferry, G.; Ubeaud, C.; Lambert, P.H.; Bertin, S.; Coge, F.; Chomarat, P.; Delagrange, P.; Serkiz, B.; Bouchet, J.P.; Truscott, R.J.W.; Boutin, J.A.
    Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase (2005), Biochem. J., 388, 205-215.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.13.11.52

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-methyl-DL-Trp
-
 Homo sapiens
2-methylindole
-
 Homo sapiens
5-hydroxy-L-Trp
-
 Homo sapiens
H2O2 at high concentrations Homo sapiens
N1-acetyl-N2-formyl-5-methoxykynurenine
-
 Homo sapiens
tryptamine
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.043
-
 L-Trp
-
 Homo sapiens
5.2
-
 D-Trp
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the oxidative metabolism of melatonin is due, in presence of H2O2, to the activities of both myeloperoxidase, EC 1.11.1.7 and indolemanine 2,3-dioxygenase ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P48775
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.38
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-Trp + O2
-
 Homo sapiens D-formylkynurenine
-
 ?
L-Trp + O2
-
 Homo sapiens L-formylkynurenine
-
 ?
additional information the oxidative metabolism of melatonin is due, in presence of H2O2, to the activities of both myeloperoxidase, EC 1.11.1.7 and indolemanine 2,3-dioxygenase Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
indoleamine 2,3-dioxygenase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.023
-
 1-methyl-DL-Trp
-
 Homo sapiens
0.072
-
 5-hydroxy-L-Trp
-
 Homo sapiens
0.158
-
 2-methylindole
-
 Homo sapiens
0.255
-
 tryptamine
-
 Homo sapiens