Cloned (Comment) | Organism |
---|---|
construction of recombinant replication-defective adenoviruses harboring the human indoleamine 2,3-dioxygenase gene and expression in dendritic cells | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | Homo sapiens | activity is increased in important biological processes, such as protection of the fetus from rejection during pregnancy and possibly T cell death in HIV-infected patients | L-formylkynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dendritic cell | CD123+/CCR6+ dendritic cells do not constitutively express indoleamine 2,3-dioxygenase, and, even if they express the enzyme after interferon-gamma treatment, they possess only limited T-cell regulatory function | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-Trp + O2 | - |
Homo sapiens | L-formylkynurenine | - |
? | |
L-Trp + O2 | activity is increased in important biological processes, such as protection of the fetus from rejection during pregnancy and possibly T cell death in HIV-infected patients | Homo sapiens | L-formylkynurenine | - |
? |