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Literature summary for 1.13.11.52 extracted from
- The heme environment of recombinant human indoleamine 2,3-dioxygenase: Structural properties and substrate-ligand interactions (2002), J. Biol. Chem., 277, 15788-15794.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-Trp + O2 | - |
Homo sapiens | L-formylkynurenine | - |
? |  |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | characterization of the heme environment, strong proximal Fe-His bond and strond H-bonding and/or steric interactions between L-Trp and dioxygen in the distal pocket are likely crucial for the enzymatic activity of the recombinant enzyme | Homo sapiens | |
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Release 2023.1 (January 2023)
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