Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | IDO can bind following substances as ligand in effector binding site: alkyl isocyanides, CN-, F-, N3-, imidazoles, pyridines, formate, benzhydroxamate, phosphines | Oryctolagus cuniculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
CO | negatively cooperative | Oryctolagus cuniculus | |
imidazole | negatively cooperative or competitive | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0065 | - |
L-tryptophan | pH 8.0 | Oryctolagus cuniculus | |
0.009 | - |
L-tryptophan | pH 7.5 | Oryctolagus cuniculus | |
0.013 | - |
L-tryptophan | pH 7.0 | Oryctolagus cuniculus | |
0.025 | - |
L-tryptophan | pH 6.5 | Oryctolagus cuniculus | |
0.05 | - |
L-tryptophan | pH 6.0 | Oryctolagus cuniculus | |
0.25 | - |
L-tryptophan | pH 5.5 | Oryctolagus cuniculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CN- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus | |
F- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus | |
N3- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-D-kynurenine | - |
? | |
L-tryptophan + O2 | Oryctolagus cuniculus | higher affinity at alkaline pH than at acidic pH | N-formyl-L-kynurenine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
small intestine | - |
Oryctolagus cuniculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-D-kynurenine | - |
? | |
L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
L-tryptophan + O2 | higher affinity at alkaline pH than at acidic pH | Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | the environmental structure of the active-site heme pocket is similar but the size is considerably larger than that of myoglobin | Oryctolagus cuniculus |